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Pagetoid reticulosis in a 13-year old female. A unique immunohistochemical profile
Juan Torre-Castro1, Loreto Carrasco Santos1, Socorro M Rodríguez-Pinilla2
1Dermatology Department, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.
Abstract:
Pagetoid reticulosis (PR) is a rare lymphoproliferative disorder with indolent behavior considered a variant of mycosis fungoides. It is characterized by marked epidermotropism of the neoplastic lymphocytes. Since its original description, five cases have been reported in children. We report a new case of PR with an immunohistochemical profile not previously described in children.
Insights
Pagetoid reticulosis (PR), a rare mycosis fungoides variant, typically affects adults. This report details a unique pediatric case of PR, highlighting an unusual immunohistochemical profile in a child.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Pagetoid reticulosis (PR) is a rare, indolent lymphoproliferative disorder.
- PR is considered a variant of mycosis fungoides, characterized by neoplastic lymphocytes in the epidermis.
- Pediatric cases of PR are exceptionally rare, with only five previously documented.
Observation:
- This study presents a novel case of Pagetoid reticulosis in a pediatric patient.
- The case exhibited a distinct immunohistochemical profile not previously observed in children with PR.
Findings:
- The reported pediatric PR case demonstrated unique immunohistochemical markers.
- This finding expands the understanding of PR heterogeneity in pediatric populations.
Implications:
- The distinct profile may necessitate tailored diagnostic and therapeutic approaches for pediatric PR.
- Further research into pediatric Pagetoid reticulosis is warranted to elucidate its specific characteristics and behavior.
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