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Related Experiment Video

Updated: Jan 2, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

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Published on: July 2, 2013

Executive functioning affects verbal learning process in multiple sclerosis patients: Behavioural and imaging

Marco Pitteri¹, Caterina Dapor¹, Anna Isabella Pisani¹

¹Neurology Section, Department of Neuroscience, Biomedicine and Movements Sciences, University of Verona, Italy.

Journal of Neuropsychology

|December 1, 2019

Summary

Executive functioning (EF) significantly impacts verbal memory in people with multiple sclerosis (pwMS). This study links EF performance and brain structure to memory deficits, informing rehabilitation strategies.

Keywords:

cortical thickness executive functioning memory multiple sclerosis verbal learning

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Eye-Tracking Control to Assess Cognitive Functions in Patients with Amyotrophic Lateral Sclerosis

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Published on: October 13, 2016

Area of Science:

Neuroscience
Cognitive Psychology
Neurology

Background:

Verbal learning and memory deficits are common in people with multiple sclerosis (pwMS).
These deficits are often linked to impairments in other cognitive functions, including information processing speed and executive functioning (EF).

Purpose of the Study:

To investigate the impact of executive functioning (EF) on verbal learning and memory in pwMS.
To examine these effects at both behavioral and neural levels using neuropsychological tests and MRI.

Main Methods:

Seventy pwMS completed a battery of neuropsychological tests assessing verbal memory (Selective Reminding Test) and EF (Stroop, Verbal Fluency, Modified Five-Point Test).
Structural MRI scans were obtained for 68 patients to calculate cortical thickness in frontal, pre-frontal, and hippocampal regions.

Main Results:

Performance on the Alternate Verbal Fluency test significantly predicted immediate and delayed verbal memory scores.
Cortical thickness in the hippocampus and several frontal regions (anterior cingulate, superior/inferior frontal gyrus, medial frontal cortex, frontal pole) correlated significantly with verbal memory performance.

Conclusions:

Executive functioning plays a significant role in verbal memory performance in pwMS.
Understanding the interplay between EF and verbal memory is crucial for developing targeted memory rehabilitation programs for pwMS.