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Selective removal of low-density lipoproteins from plasma by polyacrylate-coated Fractogel in vitro and in
K Thies1, S A Prigent, C C Heuck
1Institut für Immunologie und Serologie, Universität Heidelberg, F.R.G.
Artificial Organs
|August 1, 1988
Abstract:
Polyacrylate, covalently bound to Fractogel, was tested as a sorbent for lipoproteins from human plasma in a perfusion column. Experiments in vitro indicated complete elimination of low-density lipoproteins from citrated plasma. No binding of high-density lipoproteins, fibrinogen, or the complement factors C3 and C4 was observed. Biocompatibility was demonstrated by extracorporeal plasma perfusion in sheep. The results indicate the potential use of polyacrylate-coated Fractogel for the removal of low-density lipoproteins from plasma ex vivo.