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Effect of vitamin D deficiency on BMI in patients treated with Multi-acting Receptor Target Antipsychotics
Miloslav Kopecek1, Patrik Svancer1, Veronika Andrashko1
1National Institute of Mental Health, Klecany, Topolová 748, 250 67, Czech Republic.
Objectives:
Our aim was to examine the effect of vitamin D deficiency on BMI in patients treated with Multi-acting Receptor Target Antipsychotics (MARTA).
Methods:
We measured serum 25-hydroxyvitamin D [25(OH)D] levels and body mass index (BMI) in patients with (≥1 months) and without long-term exposure to MARTA to evaluate the role of 25(OH)D deficiency on BMI.
Results:
The BMI was significantly higher after long-term MARTA exposure in 25(OH)D-deficient patients than in non-deficient patients. No significant difference was found in antipsychotic exposure between the long-term MARTA exposure groups. The BMI was significantly higher in long-term MARTA exposure 25(OH)D-deficient patients than in 25(OH)D-deficient patients without long-term exposure.
Conclusion:
Vitamin D deficiency could be a risk factor for MARTA-induced weight gain. Further studies are necessary to replicate this finding.
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