Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

31.8K
Overview
31.8K
Hypersensitivities01:30

Hypersensitivities

6.7K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
6.7K
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.3K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.3K
Adrenergic Agonists: Therapeutic Uses01:30

Adrenergic Agonists: Therapeutic Uses

1.6K
Adrenergic agonists have diverse therapeutic uses across various medical conditions and emergencies.
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and...
1.6K
Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

2.9K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
2.9K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.3K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of atropine on time to cardiac arrest in hypoxic bradycardia: a randomised cross-over study in a porcine apnoea model.

BJA open·2026
Same author

Short stays, high needs: gender disparities in Czech forensic psychiatric inpatient care.

Frontiers in psychiatry·2025
Same author

European Resuscitation Council Guidelines 2025 Special Circumstances in Resuscitation.

Resuscitation·2025
Same author

Efficacy and safety of intravenous sufentanil administration in low-severity acute trauma as a competence of paramedics: a follow-up observational study.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2025
Same author

Analysing length of stay disparities in inpatient forensic psychiatric care: a cross-sectional study in Czechia.

International journal of mental health systems·2025
Same author

Navigating dual crises: mental health of Czech health care workers during the Ukrainian refugee influx and COVID-19 pandemic.

European journal of psychotraumatology·2025

Related Experiment Video

Updated: Jan 2, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.9K

Anaphylaxis in Public Health.

Patrik Christian Cmorej1, Marcel Nesvadba1, Alexandra Mamova2

  • 1Institute for Healthcare Disciplines, St. Elizabeth University, Bratislava, Slovakia.

Neuro Endocrinology Letters
|December 1, 2019
PubMed
Summary

Anaphylaxis, a severe allergic reaction, presents diagnostic challenges due to varying definitions and data. Key risk factors include certain medications and gluten intake, impacting public health strategies.

More Related Videos

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.9K

Related Experiment Videos

Last Updated: Jan 2, 2026

Measuring Local Anaphylaxis in Mice
07:49

Measuring Local Anaphylaxis in Mice

Published on: October 14, 2014

19.9K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

2.9K
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

3.9K

Area of Science:

  • Allergy and Immunology
  • Public Health
  • Clinical Medicine

Background:

  • Anaphylaxis incidence and prevalence are challenging to ascertain due to a lack of consensus definition and varied methodologies.
  • Anaphylaxis poses a significant public health concern, with specific risk factors identified in patient populations.

Purpose of the Study:

  • To review current literature on anaphylaxis.
  • To discuss recommended practices for anaphylaxis management in public health.
  • To highlight new findings regarding anaphylaxis triggers and risk factors.

Main Methods:

  • Literature review of recent findings on anaphylaxis.
  • Analysis of risk factors, including drug use (ramipril, metoprolol) and dietary factors (gliadin).
  • Discussion of diagnostic approaches, such as serum tryptase concentration measurement.

Main Results:

  • Anaphylaxis mortality in the US is between 0.63-0.76 per million, with 58% attributed to drug-induced anaphylaxis.
  • Ramipril and metoprolol use are identified risk factors, particularly in cardiovascular disease patients.
  • Elevated gliadin levels from excess gluten intake are associated with increased anaphylaxis incidence.

Conclusions:

  • Accurate anaphylaxis diagnosis requires considering various inflammatory mediators beyond tryptase.
  • Understanding risk factors like specific medications and diet is crucial for public health interventions.
  • Adherence to professional society guidelines is recommended for managing anaphylaxis.