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Updated: Jan 2, 2026

Analysis of Lipid Droplet Content in Fission and Budding Yeasts using Automated Image Processing
Published on: July 17, 2019
Metabolism of phospholipids in the yeast Schizosaccharomyces pombe
Roman Holič1, Lucia Pokorná1, Peter Griač1
1Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Dúbravská cesta 9, Bratislava, Slovakia.
Abstract:
The fission yeast Schizosaccharomyces pombe is an important model organism for the study of fundamental questions in eukaryotic cell and molecular biology. A plethora of cellular processes are membrane associated and/or dependent on the proper functioning of cellular membranes. Phospholipids are not only the basic building blocks of cellular membranes; they also serve as precursors to numerous signaling molecules. In this review, we describe the biosynthetic pathways leading to major S. pombe phospholipids, how these pathways are regulated, and what is known about degradation and turnover of fission yeast phospholipids. This review also addresses the synthesis, regulation and the role of water-soluble phospholipid precursors. The last chapter of the review is devoted to the use of S. pombe for the biotechnological production of value-added lipid molecules.
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