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Neurogenesis: A process ontogenically linked to brain cavities and their content, CSF
A Gato1, M I Alonso1, F Lamus1
1Departamento De Anatomía Y Radiología, Facultad De Medicina, Universidad De Valladolid, C/ Ramón Y Cajal 7, 47005, Valladolid, Spain; Laboratorio de Desarrollo y Teratología del Sistema Nervioso. Instituto de Neurociencias de Castilla y León (INCYL). Universidad de Valladolid. Valladolid, Spain.
Seminars in Cell & Developmental Biology
|December 2, 2019
Summary
Cerebrospinal Fluid (CSF) in brain cavities contains signals that regulate neural precursor cells for neurogenesis. This interaction is crucial throughout embryonic, fetal, and adult life for neuron development and brain repair.
Area of Science:
- Neuroscience
- Developmental Biology
- Cell Biology
Background:
- Neurogenesis, the formation of new neurons, is essential for central nervous system (CNS) development in vertebrates.
- Neural precursor cells differentiate within specialized neurogenic niches.
- The relationship between brain cavities, cerebrospinal fluid (CSF), and neurogenesis is critical for CNS development and maintenance.
Purpose of the Study:
- To review the intricate relationship between brain cavities, CSF, and neurogenesis.
- To elucidate how CSF-derived signals influence neural precursor cell behavior.
- To examine the ontogenic preservation of CSF-neurogenesis interactions across different life stages.
Main Methods:
- Literature review focusing on neurogenesis and cerebrospinal fluid.
- Analysis of CSF composition and its signaling properties.
- Examination of neurogenic niches across embryonic, fetal, and adult periods.
Main Results:
- CSF contains neurogenic signals that promote neural precursor proliferation and neuronal differentiation.
- The influence of CSF on neurogenesis is maintained throughout vertebrate life, despite temporal and spatial variations.
- Distinct characteristics of CSF synthesis, composition, and neurogenic niche activity define embryonic, fetal, and adult periods.
Conclusions:
- CSF-neurogenesis interaction is a fundamental process in neuron formation and replacement throughout life.
- Understanding this interaction is vital for comprehending brain development and aging.
- Targeting CSF-mediated neurogenesis may offer therapeutic potential for brain injuries and diseases.
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