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Correlation between neutrophil-to-lymphocyte ratio and kidney dysfunction in undiagnosed hypertensive population from

Chen Chen1, Hai Yan Zhao1, Yin Hua Zhang1,2,3

  • 1Yanbian University Hospital, Clinical Research Center, Yanji, China.

Journal of Clinical Hypertension (Greenwich, Conn.)
|December 2, 2019
PubMed

Insights

Neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) can indicate kidney issues in hypertensive individuals. NLR shows a positive association with kidney function markers in hypertension patients.

Area of Science:

  • Clinical Medicine
  • Biomarkers
  • Nephrology

Background:

  • Neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) are emerging biomarkers for disease assessment.
  • Hypertension (HTN) is a major risk factor for kidney disease, necessitating early detection methods.

Purpose of the Study:

  • To investigate the association between NLR and MLR with kidney function in undiagnosed hypertensive individuals from the general population.
  • To compare these associations with liver function parameters.

Main Methods:

  • Analysis of data from 15,219 participants undergoing routine health checkups, with 4,997 identified as hypertensive.
  • Pearman correlation analysis and tertile analysis of NLR and MLR in relation to kidney function markers (CREA, BUN) and liver function tests.
  • Stratification by hypertension status, age, and gender.

Main Results:

  • Hypertensive individuals exhibited significantly higher NLR, MLR, and kidney/liver function markers.
  • NLR positively correlated with systolic blood pressure and CREA in hypertensive individuals.
  • NLR was associated with BUN and CREA across all tertiles in hypertensive individuals, suggesting a consistent relationship with kidney function.

Conclusions:

  • NLR serves as a cost-effective predictor of kidney abnormalities in hypertensive patients within the general population.
  • The association between NLR/MLR and kidney function is more pronounced in hypertensive individuals compared to non-hypertensives.

Keywords:
general populationhypertensionkidney functionmonocyte-to-lymphocyte rationeutrophil-to-lymphocyte ratio

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