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Current Smoking Is Increased in Axial Psoriatic Arthritis and Radiographic Sacroiliitis
Dilek Solmaz1, Umut Kalyoncu1, Ilaria Tinazzi1
1From the University of Ottawa Faculty of Medicine, Rheumatology, and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Hacettepe University Hospital, Ankara, Turkey; Unit of Rheumatology, Sacro Cuore-Don Calabria Hospital, Negrar, Verona, Italy; Ege University, Department of Internal Medicine, Division of Rheumatology, Izmir, Turkey; Suleyman Demirel University, Department of Internal Medicine, Division of Rheumatology, Isparta, Turkey; Uludag University, Department of Internal Medicine, Division of Rheumatology, Bursa, Turkey; Mustafa Kemal University, Department of Internal Medicine, Division of Rheumatology, Hatay, Turkey; Diskapi Yildirim Beyazit Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey; Kahramanmaras Sutcu Imam University, Department of Internal Medicine, Division of Rheumatology, Kahramanmaras, Turkey; Ankara Numune Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey; Marmara University, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey; Selcuk University, Department of Internal Medicine, Division of Rheumatology, Konya, Turkey. D. Solmaz had funding from Union ChimiqueBelge (UCB) for an axial spondyloarthritis fellowship. S. Bakirci had funding from the Turkish Society for Rheumatology (TRD). S.Z. Aydin received honoraria from Abbvie, Celgene, UCB, Novartis, Jannsen, and Sanofi. D. Solmaz, MD, University of Ottawa Faculty of Medicine, Rheumatology; U. Kalyoncu, MD, Associate Professor, Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology; I. Tinazzi, MD, Unit of Rheumatology, Sacro Cuore-Don Calabria Hospital; S. Bakirci, MD, University of Ottawa Faculty of Medicine, Rheumatology; O. Bayindir, MD, Ege University, Department of Internal Medicine, Division of Rheumatology; A. Dogru, MD, Suleyman Demirel University, Department of Internal Medicine, Division of Rheumatology; E. Dalkilic, MD, Associate Professor, Uludag University, Department of Internal Medicine, Division of Rheumatology; G. Kimyon, MD, Mustafa Kemal University, Department of Internal Medicine, Division of Rheumatology; C. Ozisler, MD, Diskapi Yildirim Beyazit Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology; G.Y. Cetin, MD, Associate Professor, Kahramanmaras Sutcu Imam University, Department of Internal Medicine, Division of Rheumatology; L. Kilic, MD, Hacettepe University, Department of Internal Medicine, Division of Rheumatology, Hacettepe University Hospital; A. Omma, MD, Ankara Numune Education and Research Hospital, Department of Internal Medicine, Division of Rheumatology; M. Can, MD, Associate Professor, Marmara University, Department of Internal Medicine, Division of Rheumatology; S. Yilmaz, MD, Professor, Selcuk University, Department of Internal Medicine, Division of Rheumatology; A. Erden, MD, Hacettepe University, Department of Internal Medicine, Division of Rheumatology; S.Z. Aydin, MD, Associate Professor, University of Ottawa Faculty of Medicine, Ottawa Hospital Research Institute. Address correspondence to Dr. S.Z. Aydin, 1967 Riverside Drive, Ottawa, Ontario K1H 7W9, Canada. E-mail: saydin@toh.ca. Accepted for publication November 13, 2019.
Objective:
The effect of smoking in psoriatic arthritis (PsA) is under debate. Our aim was to test whether smoking is increased in axial PsA (axPsA).
Methods:
Included in the analysis were 1535 patients from PsArt-ID (PsA-International Database). The effect of smoking on axPsA (compared to other PsA phenotypes) and radiographic sacroiliitis were investigated.
Results:
Current smoking was more common in axPsA (28.6% vs 18.9%, p < 0.001). It also was found as an independent predictor of axPsA (OR 1.4) and radiographic sacroiliitis (OR 6.6).
Conclusion:
Current smoking is significantly associated with both axPsA and radiographic sacroiliitis in patients with PsA.
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