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Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients
Hirotaka Watanabe1, Sho Yoneda1, Yuichi Motoyama2
1Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan.
Abstract:
Gastrin regulates gastric acid secretion, and gastrin secretion itself is regulated by the negative feedback system of gastric acidity. Autoimmune gastritis (AG) is a disease where parietal cells are destroyed, resulting in decreased acid production and an elevated serum gastrin level. We herein report 2 AG cases with marked hypergastrinemia (>5,000 pg/mL). In both cases, 24-hour gastric pH monitoring showed no time when gastric pH was <2, and immunohistochemistry revealed more than 140 gastrin-positive cells per linear millimeter at the antral mucosa. This is the first report to confirm the relationship between marked hypergastrinemia and G-cell hyperplasia with AG.
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