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Role of apoptosis repressor with caspase recruitment domain (ARC) in cancer

Zhongjie Yu1,2, Qi Li3, Yi An4

  • 1Center for Molecular Genetics, Institute for Translational Medicine, Qingdao University, Qingdao, Shandong 266000, P.R. China.

Oncology Letters
|December 3, 2019
PubMed

Insights

Apoptosis repressor with caspase recruitment domain (ARC) inhibits apoptosis and is upregulated in tumors, promoting therapeutic resistance. Understanding ARC

Area of Science:

  • Molecular biology
  • Cell biology
  • Oncology

Background:

  • Apoptosis repressor with caspase recruitment domain (ARC) is a key regulator of apoptosis, crucial for cell fate.
  • ARC is highly expressed in terminally differentiated cells like neurons and muscle cells.
  • Aberrant ARC expression is linked to abnormal cell growth and various cancers.

Purpose of the Study:

  • To review the characteristics and cytoprotective functions of ARC.
  • To explore the molecular mechanisms underlying ARC's role in cell fate and cancer.
  • To evaluate ARC as a potential therapeutic target in oncology.

Main Methods:

  • Literature review of existing studies on ARC.
  • Analysis of ARC expression patterns in normal and cancerous tissues.
  • Examination of ARC's involvement in apoptosis regulation and therapeutic resistance.

Main Results:

  • ARC is upregulated in several solid tumors, suppressing cancer cell apoptosis.
  • Elevated ARC levels in cancer cells correlate with therapeutic resistance and poor clinical outcomes, particularly in leukemia.
  • ARC's precise role and molecular mechanisms in cancer require further elucidation.

Conclusions:

  • ARC plays a significant cytoprotective role under various conditions.
  • ARC's involvement in promoting cancer cell survival and therapeutic resistance highlights its potential as a novel cancer therapy target.
  • Further research into ARC's mechanisms could unlock new therapeutic strategies for cancer treatment.
Keywords:
apoptosisapoptosis repressor with caspase recruitment domaincancercytoprotectiontarget therapy

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