Related Experiment Video For hepatocellular carcinoma
Updated: Jan 2, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
Mitotically-associated long non-coding RNA promotes cancer cell proliferation in hepatocellular carcinoma by
Xuejing Zhang1, Hongling Li1, Mingfeng Mao1
1Department of Medical Ultrasonics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China.
Abstract:
Mitotically-associated long non-coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR)-122a was downregulated HCC and was inversely correlated with MANCR only in cancer tissues. MANCR overexpression resulted in downregulation of miR-122a, while miR-122a overexpression showed no obvious effects on MANCR expression. MANCR overexpression showed no significant effects on HCC cell proliferation but led to promoted cell migration and invasion. miR-122a overexpression led to inhibited migration and invasion of HCC cells and attenuated the effects of MANCR overexpression. Therefore, lncRNA MANCR may promote cancer cell proliferation in HCC by downregulating miR-122a.
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