Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

285
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
285
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

1.3K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.3K
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

2.7K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.7K
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

196
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
196

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topical vancomycin for surgical site infection prophylaxis in craniotomies and noninstrumented spinal procedures: a randomized controlled trial.

Journal of neurosurgery·2025
Same author

Systematic review of novel technology-based interventions for ischemic stroke.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2021
Same author

A phase II randomized controlled trial of tiopronin for aneurysmal subarachnoid hemorrhage.

Journal of neurosurgery·2019
Same author

Location-specific differences in hematoma volume predict outcomes in patients with spontaneous intracerebral hemorrhage.

International journal of stroke : official journal of the International Stroke Society·2019
Same author

Statins and perihemorrhagic edema in patients with spontaneous intracerebral hemorrhage.

Neurology·2019
Same author

Functional Coagulation Differences Between Lobar and Deep Intracerebral Hemorrhage Detected by Rotational Thromboelastometry: A Pilot Study.

Neurocritical care·2019

Related Experiment Video

Updated: Jan 2, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.4K

Statin Therapy in Ischemic Stroke Models: A Meta-Analysis.

Brandon Christophe1, Maham Karatela2, Joanly Sanchez1

  • 1Department of Neurological Surgery, Columbia University Medical Center, 630 West 168th Street, Physicians and Surgeons 5-454, New York, NY, 10032, USA.

Translational Stroke Research
|December 3, 2019
PubMed
Summary

Statins significantly reduce stroke damage, including infarct and edema, with specific types and subcutaneous injection showing best results. This meta-analysis clarifies optimal dosing for improved neuroprotection and clinical care.

Keywords:
Animal modelsCerebral ischemiaMeta-analysisStatinsStroke

More Related Videos

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery
07:26

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Published on: May 24, 2021

8.1K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.4K

Related Experiment Videos

Last Updated: Jan 2, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
06:01

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia

Published on: August 18, 2015

15.4K
Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery
07:26

Modeling Stroke in Mice: Transient Middle Cerebral Artery Occlusion via the External Carotid Artery

Published on: May 24, 2021

8.1K
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

12.4K

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cardiovascular Research

Background:

  • Statins are known for lipid lowering and cardiovascular disease reduction.
  • Retrospective studies suggest statins offer neuroprotection after ischemic stroke.
  • Inconsistent dosing and a need for comprehensive review on edema and blood-brain barrier (BBB) effects limit current understanding.

Purpose of the Study:

  • To conduct a meta-analysis of statin administration in animal models of ischemic stroke.
  • To determine the most effective statin dosing regimens for infarct, edema, BBB breakdown, and functional outcomes.
  • To explore statins' effects on edema and BBB breakdown for enhanced neuroprotection insights.

Main Methods:

  • A systematic search of PubMed, Web of Science, and Embase for murine studies using statins after transient middle cerebral artery occlusion (tMCAO).
  • Meta-analysis and meta-regression using standardized mean difference (SMD) for continuous outcomes.
  • Bias assessment using SYRCLE's RoB tool; data extraction included statin type, dose, administration, and outcomes.

Main Results:

  • Statin administration significantly reduced infarct volume (p < 0.0001), edema volume (p < 0.002), and neurological deficit (p < 0.0001).
  • Simvastatin and pravastatin were more effective in reducing infarct volume than atorvastatin and rosuvastatin.
  • Pravastatin showed superior functional outcomes; subcutaneous injection was the most effective administration method across all outcomes. Statin therapy reduced BBB breakdown.

Conclusions:

  • Statin therapy demonstrably improves neurological outcomes post-ischemic stroke.
  • This meta-analysis provides crucial insights into optimal statin dosing and its effects on edema and BBB breakdown.
  • Findings support future study designs and have implications for clinical management of ischemic stroke patients.