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Updated: Jan 2, 2026

The Synergistic Effect of Visible Light and Gentamycin on Pseudomona aeruginosa Microorganisms
Published on: July 2, 2013
Light-Activated Rhenium Complexes with Dual Mode of Action against Bacteria
Angelo Frei1, Maite Amado1, Matthew A Cooper1
1Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, 4072, Australia.
Abstract:
New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity against drug-resistant S. aureus and E. coli. The activity profile against mutant strains combined with assessments of cellular uptake and synergy suggest two distinct modes of action.

