Nanogels as drug-delivery systems: a comprehensive overview

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery

Background:

• Nanogels are gaining attention as nanoscopic drug carriers for targeted and controlled delivery.
• Their diverse polymer systems and tunable physicochemical properties enable multipurpose applications.
• Key advantages include high stability, drug loading capacity, biocompatibility, and stimuli-responsiveness.

Purpose of the Study:

• To provide a comprehensive review of nanogels as drug delivery systems.
• To discuss various types of nanogels, their preparation, and drug loading methods.
• To elucidate biodegradation and drug release mechanisms, and highlight recent applications.

Main Methods:

• Literature review focusing on nanogel research.
• Analysis of different nanogel preparation techniques.
• Examination of drug loading, release, and biodegradation mechanisms.

Main Results:

• Nanogels exhibit significant potential in gene delivery, chemotherapy, diagnostics, and organ targeting.
• A wide array of nanogel types and preparation methods are available.
• Understanding biodegradation and release kinetics is crucial for optimizing therapeutic outcomes.

Conclusions:

• Nanogels represent a promising platform for advanced drug delivery due to their tunable properties and versatility.
• Further research into their preparation, biodegradation, and release mechanisms will enhance their clinical utility.
• Nanogels show great potential across various biomedical fields, from therapy to diagnostics.