Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Eccentric Loading01:16

Eccentric Loading

840
Eccentric loading is a crucial concept in the study of structural engineering and mechanics, particularly when analyzing the stability and stress distribution in columns. Unlike centric loading, where the force is applied along the centroidal axis, causing uniform compression, eccentric loading occurs when a force is applied off-center. This off-center application introduces not only direct compressive stress but also bending stress, significantly influencing the column's behavior under...
840
Design of Columns under an Eccentric Load01:21

Design of Columns under an Eccentric Load

1.1K
Designing columns to withstand eccentric loads is a critical aspect of structural engineering, ensuring structures can support off-center loads without failure. This design process must account for the additional normal stresses introduced by eccentric loading, which can significantly influence a column's stress distribution and overall stability. An eccentric load applied to a column induces normal stresses that can be conceptualized as a combination of stresses due to an equivalent...
1.1K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

3.8K
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.8K
Elevation of Intermediate Points on Vertical Curves01:20

Elevation of Intermediate Points on Vertical Curves

226
Vertical curves are essential in roadway design because they provide smooth transitions between varying roadway grades. Designing vertical curves involves calculating intermediate elevations and identifying the curve's highest or lowest point, which is essential for optimal roadway performance.Intermediate elevations on a vertical curve are determined using the tangent offset method. This method considers the initial elevation at the start of the curve, the grades, and the curve's geometry. The...
226
General Case of Eccentric Axial Loading01:12

General Case of Eccentric Axial Loading

427
Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
427
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

2.2K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zeaxanthin Mitigates Hydroxychloroquine-Induced Retinal Toxicity and Metabolic Reprogramming in ARPE-19 Cells.

Journal of biochemical and molecular toxicology·2026
Same author

Non-pharmacological interventions modulating immune response in Parkinson's disease: where do we stand for future preventive approaches.

Neurochemistry international·2026
Same author

Protective role of Vaccinium myrtillus's (Bilberry) antioxidant and anti-inflammatory effects in experimental lower limb ischemia-reperfusion injury.

BMC complementary medicine and therapies·2026
Same author

Magneto-electrochemical biosensing for pathogen detection using nuclease-responsive nanohybrids.

Mikrochimica acta·2026
Same author

The effect of education, individual counseling, and labor support provided to primigravidas on birth fear, birth expectations, birth satisfaction, and perception of supportive care.

BMC pregnancy and childbirth·2026
Same author

The effect of oral cold water spray application on thirst intensity in patients undergoing spinal surgery: a randomised controlled study.

Journal of research in nursing : JRN·2026

Related Experiment Video

Updated: Jan 2, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
08:33

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

7.8K

Effects of eccentric exercise on different slopes.

Evrim Gokce1, Firat Akat1, Ali Dogan Dursun2

  • 1Ankara University Faculty of Medicine, Department of Physiology, Ankara, Turkey.

Journal of Musculoskeletal & Neuronal Interactions
|December 3, 2019
PubMed
Summary

Eccentric exercise on steeper slopes causes more muscle damage in sedentary individuals, indicated by increased creatine kinase (CK) and heat shock protein 70 (HSP70). This highlights the risk of injury from intense eccentric training.

Keywords:
Creatine KinaseEccentric ExerciseMuscular DamageNeHSP70rveSmall Animal Treadmill

More Related Videos

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.0K
Muscle Imbalances: Testing and Training Functional Eccentric Hamstring Strength in Athletic Populations
07:30

Muscle Imbalances: Testing and Training Functional Eccentric Hamstring Strength in Athletic Populations

Published on: May 1, 2018

15.8K

Related Experiment Videos

Last Updated: Jan 2, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
08:33

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans

Published on: December 11, 2016

7.8K
Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
12:59

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

13.0K
Muscle Imbalances: Testing and Training Functional Eccentric Hamstring Strength in Athletic Populations
07:30

Muscle Imbalances: Testing and Training Functional Eccentric Hamstring Strength in Athletic Populations

Published on: May 1, 2018

15.8K

Area of Science:

  • Exercise Physiology
  • Muscle Biology
  • Sports Medicine

Background:

  • Eccentric contraction, muscle lengthening under tension, can induce significant muscle damage.
  • Sedentary individuals are particularly susceptible to exercise-induced muscle injuries.
  • Understanding the impact of different eccentric exercise intensities is crucial for injury prevention.

Purpose of the Study:

  • To investigate the effects of varying eccentric exercise slopes on muscle damage markers.
  • To assess the relationship between eccentric exercise intensity and histological changes in skeletal muscle.
  • To evaluate the impact on oxidative stress and inflammatory responses.

Main Methods:

  • 32 male Wistar rats were divided into sedentary, horizontal running, and eccentric exercise groups (-8°, -16°).
  • Animals underwent 90 minutes of running at 25 m/s for five days.
  • Plasma creatine kinase (CK), heat shock protein 70 (HSP70), oxidative stress markers, and soleus muscle histology were analyzed 48 hours post-exercise.

Main Results:

  • Eccentric exercise at -16° significantly increased CK and HSP70 levels.
  • Oxidative stress increased with eccentric exercise, particularly the oxidative stress index (OSI) at -8°.
  • Histological analysis revealed mononuclear cell infiltration, increased angiogenesis, and sarcomere breaks, all correlated with exercise slope.

Conclusions:

  • Sedentary individuals are vulnerable to muscle damage from eccentric contractions, especially at steeper inclines.
  • The findings suggest a dose-dependent relationship between eccentric exercise intensity and muscle injury.
  • Rehabilitation and training programs should consider exercise intensity and slope to mitigate injury risk.