Related Experiment Video
Updated: Jan 2, 2026

Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
Published on: February 24, 2021
The Management of Postsurgical Wound Complications with Plasma Rich in Growth Factors: A Preliminary Series
1At the BTI Biotechnology Institute in Vitoria, Spain, Eduardo Anitua, PhD, MD, is Chief Executive Officer; and Ander Pino, PhD, is a scientist. Acknowledgments: Both authors are employed by BTI Biotechnology Institute, the company that developed the PRGF-Endoret technology. The authors have disclosed no other financial relationships related to this article. Submitted November 21, 2018; accepted in revised form February 15, 2019; published ahead of print November 27, 2019.
Background:
Postsurgical wound complications constitute a relevant public health issue because of their frequency. There is growing evidence regarding platelet-based autologous therapies that support their use in promoting cutaneous regeneration.
Objective:
To provide preliminary data regarding the potential benefit of plasma rich in growth factors (PRGF) in the management of postsurgical wound complications.
Design:
Three patients suffering from poorly healing severe full-thickness wounds were treated with either one or a combination of different formulations derived from their own blood: autologous clot, fibrin membrane, injectable plasma, or topical ointment. Different treatment protocols are described, and follow-up results are reported.
Results:
Within 4 to 12 months, the treated wounds healed completely with no signs of infection, tissue necrosis, or functional impairment. No adverse events were reported.
Conclusion:
Additional clinical trials with long-term follow-up periods and larger patient populations are needed to establish the efficacy of PRGF technology. However, these preliminary findings suggest that PRGF merits further randomized controlled studies exploring its capacity to accelerate re-epithelialization and restore functional integrity to cutaneous ulcers resulting from surgical complications.
More Related Videos
Related Concept Videos
Peripheral Artery Disease V: Postoperative Nursing Management
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Clot Retraction and Fibrinolysis
Clinical Applications of Epidermal Stem Cells

