Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vaccinations01:51

Vaccinations

51.0K
Overview
51.0K
Development of Immunocompetence01:22

Development of Immunocompetence

718
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
718
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

1.8K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
1.8K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

886
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
886
Cancer Vaccines01:30

Cancer Vaccines

897
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
897
Active versus Passive Immunity01:31

Active versus Passive Immunity

9.8K
Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
Active Immunity
Active immunity refers to the resistance one develops...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Quality Improvement Initiative to Optimize Fever and Neutropenia Management in Oncology Patients.

Pediatric quality & safety·2026
Same author

The Ion channel, CFTR, assembles with HIPPO pathway proteins TAZ and YAP in polycystic kidney disease.

The Journal of biological chemistry·2026
Same author

Unveiling the carbohydrate-active enzyme repertoire of Trichoderma caribbaeum IHBT through whole-genome analysis and transcriptional profiling.

Archives of microbiology·2026
Same author

IDSA 2025 Guidelines on the use of vaccines for the prevention of seasonal COVID-19, Influenza, and RSV infections in immunocompromised patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

IDSA 2025 Guidelines on the use of vaccines for the prevention of seasonal Influenza infections in immunocompromised patients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026
Same author

Design synthesis and evaluation of arylamino propoxyphenyl indoles for potential atypical antipsychotic activity.

Future medicinal chemistry·2026

Related Experiment Video

Updated: Jan 2, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.1K

Advances in vaccinating immunocompromised children.

Katrina Miller1, Katelyn Leake, Tanvi Sharma

  • 1Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.

Current Opinion in Pediatrics
|December 3, 2019
PubMed
Summary

Immunocompromised children face a high risk of vaccine-preventable infections due to under-vaccination. Optimizing vaccine administration strategies is crucial for protecting this vulnerable population.

More Related Videos

A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors
09:16

A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors

Published on: October 30, 2016

11.7K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.2K

Related Experiment Videos

Last Updated: Jan 2, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
08:52

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

11.1K
A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors
09:16

A Simple and Efficient Approach to Construct Mutant Vaccinia Virus Vectors

Published on: October 30, 2016

11.7K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

16.2K

Area of Science:

  • Pediatric Immunology
  • Vaccinology
  • Public Health

Background:

  • Immunocompromised children are a vulnerable population with low vaccine coverage.
  • Factors contributing to under-vaccination include illness severity and limited provider awareness.
  • Vaccine-preventable infections (VPIs) pose a significant risk to these children.

Purpose of the Study:

  • To review current data on VPI incidence in immunocompromised children.
  • To explore novel vaccine administration approaches.
  • To identify strategies for improving vaccine coverage in this population.

Main Methods:

  • Review of recent data on VPI incidence.
  • Analysis of new vaccine use strategies.
  • Assessment of vaccine coverage rates.
  • Evaluation of optimization strategies for vaccine administration.

Main Results:

  • Growing populations of immunocompromised children, including transplant recipients and those on biological therapies, remain at risk for VPIs.
  • Inactive vaccines are safe and immunogenic post-immunosuppression; live vaccines are generally contraindicated but show emerging safety data in select cases.
  • Maintaining up-to-date vaccination status requires vigilance and a multidisciplinary approach.

Conclusions:

  • Immunocompromised children are significantly under-vaccinated and susceptible to VPIs.
  • Optimizing vaccine administration is a critical priority for all healthcare providers caring for these children.