Related Experiment Video
Updated: Jan 2, 2026
Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
Published on: March 29, 2018
Molar incisor hypomineralisation and dental anomalies: A random or real association?
Emma Grace Walshaw1, Fiona Noble2, Robert Conville1
1Charles Clifford Dental Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, UK.
Background:
Clinical observations suggest molar incisor hypomineralisation (MIH) may present with other dental conditions.
Aims:
The study aimed to determine the prevalence and variety of dental anomalies in children presenting with MIH.
Design:
A convenience sample of children referred to a UK dental hospital was recruited. Orthopantogram radiographs, taken as part of routine care, were assessed for dental anomalies. Two calibrated examiners reviewed the films separately and determined the presence and character of anomalies.
Results:
Radiographs were obtained from 101 patients, with an age range of 6-15 years. Co-existing hypodontia was identified in 12%, with lower second premolars being the most commonly missing teeth. Concurrent ectopic first permanent molars were identified in 8%, and infraocclusion of one or more primary molars was identified in 9%. Abnormal morphology was found in 9%, including macrodont and microdont teeth. In total, 29% of patients had an associated dental anomaly. Examiners had perfect agreement using Cohen's kappa coefficient.
Conclusion:
This high prevalence of dental anomalies, particularly hypodontia, in children with MIH is a novel and clinically important finding. Further research is warranted considering the potential implications for assessment and treatment planning.
Related Concept Videos
01:15Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
01:21Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
01:31Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...