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Serpina3n: Potential drug and challenges, mini review
Mehwish Saba Aslam1, Liudi Yuan1
1Department of Microbiology and Immunology, School of Medicine, Southeast University, Nanjing, China.
Journal of Drug Targeting
|December 3, 2019
Summary
Serpina3n, a protease inhibitor, shows therapeutic potential in various diseases, especially central nervous system insults. This review compares murine Serpina3n and human SERPINA3 (α1-antichymotrypsin) roles.
Area of Science:
- Biochemistry
- Molecular Biology
- Pathology
Background:
- Serpina3n is a secretory serine protease inhibitor with diverse physiological roles.
- It impacts pathways including complement cascade, apoptosis, wound healing, and Alzheimer's disease.
- Emerging research highlights its significance in various pathologies.
Purpose of the Study:
- To review the therapeutic potential of Serpina3n/SERPINA3 in different diseases.
- To compare the biological roles and significance of murine Serpina3n and human SERPINA3 (α1-antichymotrypsin).
Main Methods:
- Literature review and synthesis.
- Comparative analysis of murine and human orthologs.
- Exploration of Serpina3n's role in disease pathology.
Main Results:
- Serpina3n exhibits a broad range of protease inhibition.
- Its implications in central nervous system insults suggest therapeutic promise.
- Structural and functional comparisons reveal conserved and distinct roles between species.
Conclusions:
- Serpina3n/SERPINA3 represents a promising therapeutic target for various diseases.
- Further research is warranted to fully elucidate its applications, particularly in CNS disorders.
- Understanding ortholog differences is crucial for translational applications.
