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Benzothiazole derivatives as anticancer agents.

Ali Irfan1, Fozia Batool1, Syeda Andleeb Zahra Naqvi1

  • 1Department of Chemistry, University of Lahore, Sargodha, Pakistan.

Journal of Enzyme Inhibition and Medicinal Chemistry
|December 3, 2019
PubMed
Summary
This summary is machine-generated.

Benzothiazole derivatives show significant anticancer activity by inhibiting carbonic anhydrase, particularly in hypoxic tumors. This review highlights their potential as novel anti-cancer drug leads.

Keywords:
Benzothiazoleanticancer agentcarbonic anhydrase inhibitordrug targetsscaffold

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Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Biochemistry

Background:

  • Benzothiazole (BTA) derivatives are heterocyclic compounds with diverse biological activities.
  • These compounds play a crucial role in inhibiting the metalloenzyme carbonic anhydrase (CA).

Purpose of the Study:

  • To review the literature over the last decade on the role of Benzothiazole derivatives as anticancer agents.
  • To explore the mechanisms of action, focusing on carbonic anhydrase inhibition.

Main Methods:

  • Extensive literature survey.
  • Analysis of studies investigating Benzothiazole derivatives against various cancer cell lines.
  • Focus on studies related to carbonic anhydrase inhibition.

Main Results:

  • Benzothiazole derivatives exhibit broad-spectrum anticancer properties.
  • Inhibition of tumor-associated carbonic anhydrase (CA) is a well-investigated mechanism.
  • These compounds show efficacy against various cancer cell lines through multiple pathways.

Conclusions:

  • Benzothiazole derivatives are promising anticancer leads.
  • Targeting tumor-associated CAs with BTA derivatives may be effective against hypoxic tumors.
  • Further research is needed to understand less-studied mechanisms of action.