Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.7K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.7K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.4K
3.4K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

13.0K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
13.0K
MicroRNAs01:22

MicroRNAs

3.7K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.7K
MicroRNAs01:22

MicroRNAs

23.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.8K
Types of RNA01:20

Types of RNA

8.7K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
8.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence Summary for Ultrasound-Guided Peripheral Arterial Catheter Placement in Adult Critical Care Patients.

Health science reports·2026
Same author

Electronic health record-derived care-exposure burden and central line-associated bloodstream infection among critically ill adults: a multi-source retrospective cohort study.

Frontiers in public health·2026
Same author

Improving strontium (Sr) phytoremediation efficiency in Sorghum bicolor × sudanense through nitrogen management and a microbial combination.

Environmental geochemistry and health·2026
Same author

Panax quinquefolius saponins promote remyelination via orchestrating HMGCS1-NPC1-MAL-mediated lipid metabolism and rebalancing JAK-STAT signaling in a cuprizone-induced demyelination model.

Journal of ethnopharmacology·2026
Same author

Disseminated <i>Mycobacterium avium</i> Complex Infection in an HIV Patient with a History of <i>Talaromyces marneffei</i>: Diagnostic Value of Blind Subculture and Suspected Management Challenges of Immune Reconstitution Inflammatory Syndrome.

Infection and drug resistance·2026
Same author

Ink-Printed Thermoelectric Materials and Devices: Material Preparation, Fabrication Techniques, and Applications.

Small science·2026

Related Experiment Video

Updated: Jan 2, 2026

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.8K

Long non-coding RNA in lung cancer.

Zhenyao Chen1, Tianyao Lei1, Xin Chen1

  • 1Cancer Medical Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 3, 2019
PubMed
Summary

Long non-coding RNAs (lncRNAs) are key regulators in lung cancer, acting as either oncogenes or tumor suppressors. Understanding their roles is vital for developing new diagnostic and therapeutic strategies.

Keywords:
DiagnosisLong non-coding RNALung cancerTherapy

More Related Videos

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.0K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.1K

Related Experiment Videos

Last Updated: Jan 2, 2026

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.8K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

1.0K
RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

26.1K

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer is a leading cause of cancer mortality globally, with low survival rates attributed to diagnostic challenges and limited treatments.
  • Long non-coding RNAs (lncRNAs) have emerged as critical regulators of gene expression involved in various diseases, including cancer.

Purpose of the Study:

  • To review the roles of oncogenic and tumor-suppressive lncRNAs in lung cancer.
  • To discuss the biological functions and regulatory mechanisms of lncRNAs in lung cancer progression.
  • To explore the potential clinical significance of lncRNAs for lung cancer diagnosis and treatment.

Main Methods:

  • Literature review of studies on lncRNAs in lung cancer.
  • Analysis of identified differentially expressed lncRNAs, including oncogenic and tumor-suppressive types.
  • Examination of lncRNA functions in cellular processes like proliferation, apoptosis, and metastasis.

Main Results:

  • Multiple differentially expressed lncRNAs have been identified in lung cancer.
  • Some lncRNAs function as oncogenes promoting tumor growth, while others act as tumor suppressors inhibiting it.
  • lncRNAs are implicated in key physiological processes influencing tumor progression.

Conclusions:

  • lncRNAs play significant roles in lung cancer, acting as either oncogenes or tumor suppressors.
  • Understanding lncRNA functions and mechanisms offers potential for novel clinical applications.
  • lncRNAs hold promise for improving early diagnosis and therapeutic strategies for lung cancer.