Etiologic role of infectious agents in uveitis

A prospective clinical and serological study of 120 consecutive patients with anterior uveitis, 15 with posterior uveitis, and 110 healthy volunteers was carried out. It appeared from our findings that infections such as syphilis and brucellosis should be suspected in non-responsive cases of anterior uveitis. Furthermore, a highly significant frequency (41%) of seropositive HSV antibodies in our patients would suggest the possibility of its role in the etiology of uveitis. In addition, specific treatment in presumptive intraocular infections would lead to marked improvement in terms of intensity and duration of the eye inflammatory process. The results also indicate that Toxoplasmosis is almost invariably associated with posterior focal uveitis.