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Updated: Jan 2, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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[The risks of selective serotonin reuptake inhibitor intake in pregnancy]

Terje Martens1, Per Damkier, Poul Videbech

  • 1terje.martens.01@regionh.dk.

Ugeskrift for Laeger
|December 4, 2019
PubMed

Depression in pregnancy is common and may have serious consequences for the mother and foetus when untreated. In this review, we discuss selective serotonin reuptake inhibitor (SSRI) intake in pregnancy, which has been associated with increased risk of several unwanted events. However, the evidence indicating a causal relationship between the intake of SSRI in pregnancy and most investigated outcomes is of very low certainty. Confounding by indication likely accounts for most of the observed correlations. If, for any outcomes, an increased risk exists, the number needed to harm is high, and the clinical significance is unclear.

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