Molecules with versatile biological activities bearing antipyrinyl nucleus as pharmacophore
Jyotirmaya Sahoo1, Chita Ranjan Sahoo2, Priyambada Kshiroda Nandini Sarangi3
1School of Pharmacy, ARKA Jain University, Gamharia, Seraikela, Kharsawan, Jameshedpur, Jharkand, 832108, India; Department of Pharmaceutical Chemistry, Sri Jayadev College of Pharmaceutical Sciences, Bhubaneswar, 752101, Odisha, India.
Abstract:
Antipyrine (1,2-dihydro-1,5-dimethyl-2-phenylpyrazole-3-one) in a structural frame consists of a five membered lactam pyrazolone heterocyclic ring as a pharmacophore moiety. It is evident from literature that the molecules having nitrogen bearing heterocyclic nuclei clearly exhibit several biological actions. Commercially available pyrazolone derivatives as drugs, analgin and metamizol are an established chemical class of analgesics. Recent trends of synthetic routes and several biological actions of antipyrine analogues are considered in this review. Indeed, the synthesized derivatives possess antipyrine moiety having versatile biological properties, antimicrobial, antitubercular, anthelmintic, antioxidant, analgesic, anti-inflammatory, cytotoxic and antiviral activities.
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