Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

11.5K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
11.5K
Amyloid Fibrils03:03

Amyloid Fibrils

6.2K
6.2K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

308
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
308
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

375
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
375
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

442
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
442
Layers of the Heart Wall01:15

Layers of the Heart Wall

4.7K
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gene-set and proteomic signatures associated with survival after in-hospital cardiac arrest.

Resuscitation plus·2026
Same author

Variation in Vasoactive Treatment Selection for Cardiogenic Shock: Insights From the Critical Care Cardiology Trials Network (CCCTN).

Circulation. Heart failure·2026
Same author

Time to Quadruple Therapy After Initial Diagnosis of Heart Failure With Reduced Ejection Fraction.

JAMA cardiology·2026
Same author

Approach to Mitral Regurgitation in Advanced Heart Failure.

Heart failure clinics·2026
Same author

Navigating Complexity: Contemporary Patient Selection and Advanced Therapies in Heart Failure.

Heart failure clinics·2026
Same author

After the Code: The Space That Follows.

Journal of the American College of Cardiology·2026

Related Experiment Video

Updated: Jan 2, 2026

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
15:04

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

6.3K

Amyloid and the Heart.

Aaron M Wolfson1, Kevin S Shah2, Jignesh K Patel3,4

  • 1Sarver Heart Center, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ, 85724, USA.

Current Cardiology Reports
|December 4, 2019
PubMed
Summary
This summary is machine-generated.

Amyloid cardiomyopathy (AC) outcomes are improving with earlier diagnosis and new treatments. This review covers AC pathophysiology, diagnosis, and emerging therapies for light-chain (AL) and transthyretin (ATTR) AC.

Keywords:
Cardiac amyloidosisEndomyocardial biopsyRestrictive cardiomyopathy

More Related Videos

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.5K
Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
08:31

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

Published on: July 26, 2018

10.8K

Related Experiment Videos

Last Updated: Jan 2, 2026

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
15:04

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

6.3K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.5K
Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction
08:31

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

Published on: July 26, 2018

10.8K

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Amyloidosis Research

Background:

  • Amyloid cardiomyopathy (AC) presents significant morbidity and mortality.
  • Increased awareness and diagnostic advancements are improving patient outcomes.
  • This review focuses on light-chain (AL) and transthyretin (ATTR) AC.

Purpose of the Study:

  • To review the pathophysiology of amyloid cardiomyopathy.
  • To discuss contemporary diagnostic strategies for AC.
  • To explore novel and investigational therapeutic strategies for AL and ATTR AC.

Main Methods:

  • Review of current literature on AC diagnosis and treatment.
  • Analysis of recent findings in pharmacotherapy and advanced heart therapies.
  • Synthesis of information on emerging treatment modalities.

Main Results:

  • Cardiac MRI and bone scintigraphy are key diagnostic tools.
  • Front-line therapy for AL AC includes proteasome inhibitors and stem cell transplantation.
  • Tafamadis (TTR-stabilizer) is FDA-approved for ATTR AC; gene-silencing and fibril degradation therapies are under investigation.

Conclusions:

  • Patient outcomes for AC are improving due to earlier diagnosis and prompt treatment.
  • Emerging pharmacotherapies and advanced heart therapies offer new hope for AC patients.
  • Continued research into novel treatments is crucial for further improving AC outcomes.