Related Experiment Video
Updated: Jan 2, 2026
07:25
Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment
Published on: March 1, 2024
2.9K
Active Targeting Towards and Inside the Brain based on Nanoparticles: A Review
Morteza Rabiei1, Soheila Kashanian1,2,3, Seyedeh S Samavati1
1Department of Nanobiotechnology, Razi University, Kermanshah, Iran.
Current Pharmaceutical Biotechnology
|December 4, 2019
Summary
Nanoparticles (NPs) offer a promising solution for delivering therapeutics across the blood-brain barrier (BBB) to treat neurological diseases. Optimized NPs can target specific brain regions, enhancing treatment efficacy for conditions like Alzheimer's and Parkinson's.
Area of Science:
- Neuroscience
- Biotechnology
- Nanomedicine
Background:
- Neurological disease treatment is challenging due to the brain's tissue coherence.
- The blood-brain barrier (BBB) restricts drug entry, allowing only essential substances.
Purpose of the Study:
- To explore nanotechnology's role in overcoming the BBB for neurological disease treatment.
- To review methods for actively targeting specific brain areas using nanoparticles.
Main Methods:
- Utilizing nanoparticles (NPs) for drug delivery.
- Designing NPs with specific dimensions, hydrophobicity, charge, and functionalization for BBB penetration.
Main Results:
- Nanoparticles (NPs) can be engineered to traverse the blood-brain barrier (BBB).
- Optimized NPs can accumulate within brain tissue.
Conclusions:
- Nanoparticles (NPs) facilitate targeted drug delivery for neurological disorders including Alzheimer's, Parkinson's, stroke, and glioma.
- This approach enhances therapeutic potential for various brain conditions.
Keywords:
Neurological diseasesblood-brain barrierhydrophobicitynanoparticlesnanotechnologytargeted delivery.
