Jove
Visualize
Contact Us

Related Concept Videos

Ionic Crystal Structures02:42

Ionic Crystal Structures

16.6K
Ionic crystals consist of two or more different kinds of ions that usually have different sizes. The packing of these ions into a crystal structure is more complex than the packing of metal atoms that are the same size.
Most monatomic ions behave as charged spheres, and their attraction for ions of opposite charge is the same in every direction. Consequently, stable structures for ionic compounds result (1) when ions of one charge are surrounded by as many ions as possible of the opposite...
16.6K
Crystal Field Theory - Octahedral Complexes02:58

Crystal Field Theory - Octahedral Complexes

30.2K
Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
30.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of electron diffraction to rapid structural elucidation of crude reaction products.

Communications chemistry·2026
Same author

Tunable synaptic memory response using organic regioisomeric donor-acceptor-donor luminophore triads.

Chemical science·2026
Same author

Photofracking-Assisted Enhancement of Solid-State Photochemical Reactivity: α-Azido-5-phenyl-2,4-dienoate Derivatives.

Journal of the American Chemical Society·2026
Same author

Flexible Organic Radical Cocrystal With 94% Photothermal Conversion Efficiency.

Angewandte Chemie (International ed. in English)·2026
Same author

Photo Capture of Water by Single Crystals of a Nonporous Metal-Organic Material.

Journal of the American Chemical Society·2026
Same author

Organic Crystal-MXene Composites as Temperature-Tolerant Strain Sensors.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 2, 2026

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening
14:04

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

Published on: January 16, 2021

5.0K

Efficient Screening for Ternary Molecular Ionic Cocrystals Using a Complementary Mechanosynthesis and Computational

Abeer F Shunnar1, Bhausaheb Dhokale1, Durga Prasad Karothu2

  • 1Department of Chemistry, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, UAE.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 4, 2019
PubMed
Summary

Mechanochemical ball milling reproducibly synthesizes molecular ionic cocrystals (ICCs) of active pharmaceutical ingredients (APIs). This method, combined with crystal structure prediction, aids in understanding and targeting ICC formation for improved drug properties.

Keywords:
X-ray diffractioncrystal engineeringcrystal structure predictiongreen chemistrymechanosynthesismolecular ionic cocrystals

More Related Videos

Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry
16:11

Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry

Published on: June 8, 2022

2.7K
Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.7K

Related Experiment Videos

Last Updated: Jan 2, 2026

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening
14:04

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

Published on: January 16, 2021

5.0K
Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry
16:11

Thermochemical Studies of NiII and ZnII Ternary Complexes Using Ion Mobility-Mass Spectrometry

Published on: June 8, 2022

2.7K
Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
11:04

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

9.7K

Area of Science:

  • Materials Science
  • Crystallography
  • Pharmaceutical Chemistry

Background:

  • Molecular ionic cocrystals (ICCs) offer potential for optimizing active pharmaceutical ingredients (APIs) and co-delivering multiple drugs.
  • Understanding the crystallization factors of ICCs is crucial but currently limited, with many discoveries occurring serendipitously.

Purpose of the Study:

  • To establish a reliable method for synthesizing ternary molecular ICCs.
  • To investigate the thermodynamic stability and predict the crystal structures of these ICCs.
  • To explore the potential of combining mechanosynthesis with computational methods for targeted ICC design.

Main Methods:

  • Mechanochemical synthesis using ball milling for ternary molecular ICCs, with and without solvent.
  • Computational Crystal Structure Prediction (CSP) for ternary molecular ICCs.
  • Periodic dispersion-corrected Density Functional Theory (DFT) calculations to assess thermodynamic stability.

Main Results:

  • Reproducible synthesis of ternary molecular ICCs was achieved in under 30 minutes via ball milling.
  • Computational CSP accurately predicted the observed crystal structures of all synthesized ICCs.
  • DFT calculations confirmed the thermodynamic stability of the studied ICCs relative to physical mixtures.

Conclusions:

  • Mechanochemical ball milling is a versatile and rapid technique for reproducible ICC synthesis.
  • The combination of mechanosynthesis and CSP provides a powerful approach for designing and targeting specific ICCs.
  • This integrated strategy can facilitate the development of higher-order molecular ICCs with desired functional properties.