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Updated: Jan 2, 2026
Generation of Self-assembled Vascularized Human Skin Equivalents
Published on: February 12, 2021
Cutaneous vessel features of sensitive skin and its underlying functions
Wen-Cai Jiang1,2, Hui Zhang3, Yafei Xu1
1Skin and Cosmetic Research Department, Shanghai Dermatology Hospital, Shanghai, China.
Background:
Following the sufficient studies of the effects of skin barrier impairment and heightened neural reaction on sensitive skin (SS), many scholars have paid great attention to the roles of superficial microvasculature in SS.
Methods:
By questionnaire survey, lactic acid sting test, and capsaicin test, eligible subjects were classified as normal skin, only lactic acid sting test positive (LASTP), only capsaicin test positive (CATP), and both positive (both LASTP and CATP). D-OCT was used to photograph images for evaluating the cutaneous vessels features each group.
Results:
Totally 137 subjects completed the study. Compared with LASTN group, the vascular vessels were closer to epidermis in LASTP group. Mesh and branching vessels were more popular in SS than normal skin. High blood vessel density was more prevalent in SS, while low density frequently presented in normal skin. The vascular depth had a closely negative correlation with face flushing and SSS, and vascular shapes had a good positive correlation with face flushing and SSB.
Conclusions:
Our study indicates that there is a significant difference in vascular depth, shape, and density between SS and normal skin which is valuable to explore SS pathologic mechanism and to further investigate cutaneous microvasculature functions in SS.
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