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Related Experiment Videos

Parity-associated reductions in behavioral sensitivity to opiates.

C H Kinsley1, R S Bridges

  • 1Harvard Medical School, Department of Anatomy and Cellular Biology, Boston, Massachusetts 02115.

Biology of Reproduction
|September 1, 1988
PubMed
Summary

Multiparous female rodents show increased resistance to the effects of morphine on maternal behavior compared to primiparous females. This suggests differences in opioid sensitivity related to maternal experience.

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Area of Science:

  • Neuroscience
  • Behavioral Biology
  • Reproductive Science

Background:

  • Maternal behavior in rodents differs significantly between primiparous (first-time mothers) and multiparous (experienced mothers) females.
  • Opiates are known to inhibit maternal behavior, an effect reversible by naloxone, an opiate antagonist.

Purpose of the Study:

  • To investigate if multiparous females exhibit greater resistance to the inhibitory effects of opiates on maternal behavior compared to primiparous females.
  • To explore the role of opioid system sensitivity in experienced versus naive maternal care.

Main Methods:

  • Experiment 1: Assessed effects of various morphine sulfate (MS) doses on maternal behavior in primiparous rats.
  • Experiment 2: Compared maternal behavior in primiparous and multiparous rats after daily MS injections during lactation.

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  • Experiment 3: Measured analgesic responses to MS in primigravid, multigravid, and postpartum lactating rats using a tail-flick test.

    • Main Results:

    • Morphine sulfate (5.0 and 10.0 mg/kg) disrupted maternal behavior in primiparous rats.
    • Multiparous rats were significantly less affected by MS-induced disruption of maternal behavior than primiparous rats, with resistance increasing by lactation Day 10.
    • Multigravid females showed reduced analgesic responses to MS prepartum compared to primigravid females, indicating potentially lower endogenous opioid sensitivity.

    Conclusions:

    • Multiparous females display a heightened resistance to the disruptive effects of opiates on maternal behavior, suggesting experience-dependent alterations in opioid signaling.
    • Reduced analgesic sensitivity in multigravid females supports the hypothesis of differential opioid system engagement across parity and pregnancy status.