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Xanthones and Cancer: from Natural Sources to Mechanisms of Action
Luiz C Klein-Júnior1, Adriana Campos1, Rivaldo Niero1
1Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí - UNIVALI, 88302-901, Itajaí, Brazil.
Abstract:
Xanthones are a class of heterocyclic natural products that have been widely studied for their pharmacological potential. In fact, they have been serving as scaffolds for the design of derivatives focusing on drug development. One of the main study targets of xanthones is their anticancer activity. Several compounds belonging to this class have already demonstrated cytotoxic and antitumor effects, making it a promising group for further exploration. This review therefore focuses on recently published studies, emphasizing their natural and synthetic sources and describing the main mechanisms of action responsible for the anticancer effect of promising xanthones.
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