Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

798
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
798
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

227
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
227
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

478
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
478
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

327
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
327
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

243
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
243
Cardiac Catheterization I: Pre-Procedure Overview01:28

Cardiac Catheterization I: Pre-Procedure Overview

921
Cardiac catheterization is an invasive diagnostic technique used to identify and evaluate structural and functional diseases of the heart and major blood vessels. This technique diagnoses congenital heart disease, coronary artery disease, valvular heart disease, and coronary spasms and assesses ventricular function. It helps guide treatment decisions, including the need for revascularization procedures like percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) and...
921

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing Approaches to Estimation of Anesthesia Agent and Gas Consumption: A Single-Center Retrospective Analysis.

Anesthesia and analgesia·2026
Same author

Feasibility Pilot Trial for the Trajectories of Recovery after Intravenous Propofol versus Inhaled Volatile Anesthesia (THRIVE) Pragmatic Randomized Clinical Trial.

Anesthesiology·2026
Same author

2025 Clinical Update in Liver Transplantation.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

The effect of hospital-level fine particulate matter exposure on surgical complications.

Anaesthesia·2026
Same author

Patient-, Clinician-, and Institution-level Variation in Intraoperative Antihypertensive Use: A Multicenter Observational Analysis.

Journal of cardiothoracic and vascular anesthesia·2026
Same author

Should Centralization of Organ Donation at Donor Care Units Become the Criterion Standard?

JAMA network open·2026

Related Experiment Video

Updated: Jan 2, 2026

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.5K

Preoperative Risk and the Association between Hypotension and Postoperative Acute Kidney Injury.

Michael R Mathis1, Bhiken I Naik, Robert E Freundlich

  • 1From the University of Michigan Medical School, Departments of Anesthesiology (M.R.M., A.M.S., M.L.B., D.A.C., A.J., M.C.E., L.S., K.K.T., S.K.) Internal Medicine (M.H.), Ann Arbor, Michigan University of Virginia Health System, Department of Anesthesiology and Neurosurgery, Charlottesville, Virginia (B.I.N.) Vanderbilt University Medical Center, Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine, Nashville, Tennessee (R.E.F.) Columbia University Medical Center, Department of Anesthesiology, New York, New York (M.K.) University of Chicago Medical Center, Department of Anesthesia and Critical Care, Chicago, Illinois (G.R.). Oregon Health & Science University, Department of Anesthesiology, Portland, Oregon Saint Joseph Mercy Health System, Department of Anesthesiology, Ann Arbor, Michigan University of Virginia Health System, Department of Anesthesiology, Charlottesville, Virginia University of Pennsylvania Health System, Department of Anesthesiology, Philadelphia, Pennsylvania Columbia University Medical Center, Department of Anesthesiology, New York, New York Beaumont Hospital of Troy, Michigan, Department of Anesthesiology, Troy, Michigan Beaumont Hospital of Dearborn, Michigan, Department of Anesthesiology, Dearborn, Michigan Columbia University Medical Center, Department of Anesthesiology, New York, New York Beaumont Health, Farmington Hills, Michigan University of Oklahoma Health Sciences Center, Department of Anesthesiology, Oklahoma City, Oklahoma Bronson Healthcare, Kalamazoo, Michigan University of Tennessee Medical Center, Department of Anesthesiology, Knoxville, Tennessee Cleveland Clinic, Anesthesiology Institute, Cleveland, Ohio St. Joseph Mercy Oakland, Pontiac, Michigan Weill Cornell Medical College, Department of Anesthesiology, New York, New York Washington University School of Medicine, Department of Anesthesiology, St. Louis, Missouri University of Colorado, Department of Anesthesiology, Aurora, Colorado University Medical Center Utrecht, Department of Anesthesiology, Utrecht, The Netherlands Academic Medical Center, Department of Anesthesiology, Amsterdam, The Netherlands Mercy Health, Muskegon, Michigan Bronson Healthcare, Battle Creek, Michigan Wake Forest School of Medicine, Department of Anesthesiology, Winston-Salem, North Carolina St. Mary Mercy Hospital, Livonia, Michigan University of Washington, Department of Anesthesiology and Pain Medicine, Seattle, Washington University of Vermont College of Medicine, Department of Anesthesiology, Burlington, Vermont Sparrow Health System, Lansing, Michigan NYU Langone Medical Center, Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York, New York Vanderbilt University Medical Center, Department of Anesthesiology, Nashville, Tennessee Holland Hospital, Holland, Michigan.

Anesthesiology
|December 4, 2019
PubMed
Summary

Intraoperative hypotension is linked to acute kidney injury in noncardiac surgery, but the risk varies with patient preoperative risk. Absolute hypotension, not relative, is a key factor, especially in high-risk patients.

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.8K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.8K

Related Experiment Videos

Last Updated: Jan 2, 2026

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock
07:48

Noninvasive and Invasive Renal Hypoxia Monitoring in a Porcine Model of Hemorrhagic Shock

Published on: October 28, 2022

1.5K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.8K
Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
03:13

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Published on: November 3, 2023

2.8K

Area of Science:

  • Anesthesiology
  • Nephrology
  • Critical Care Medicine

Background:

  • Acute kidney injury (AKI) poses a significant healthcare burden, yet prevention strategies remain poorly understood.
  • Previous studies suggest a link between hypotension and postoperative AKI, but generalizability and the influence of patient risk factors are unclear.

Purpose of the Study:

  • To investigate if the association between intraoperative hypotension and acute kidney injury differs based on preoperative patient risk.
  • To analyze the interaction between hypotension and baseline disease burden in the context of AKI development.

Main Methods:

  • A retrospective review of 138,021 major noncardiac surgical procedures across eight hospitals (2008-2015).
  • Patients were stratified into preoperative risk quartiles based on comorbidities and surgical procedure.
  • Intraoperative hypotension was defined by mean arterial pressure thresholds (absolute or relative), and its association with AKI was analyzed.

Main Results:

  • 9.0% of patients developed postoperative AKI.
  • No association between hypotension and AKI was found in low-risk patients.
  • In medium-risk patients, severe hypotension (MAP < 50 mmHg) increased AKI risk (aOR 2.62).
  • In high-risk patients, mild hypotension (MAP 55-59 mmHg) was associated with AKI (aOR 1.34).
  • Absolute hypotension showed stronger associations than relative hypotension.

Conclusions:

  • The association between intraoperative hypotension and acute kidney injury in noncardiac surgery is dependent on preoperative risk stratification.
  • Absolute hypotension, at specific thresholds, is an independent risk factor for AKI, particularly in higher-risk patient groups.
  • Relative hypotension did not show consistent associations with AKI in this study.