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Monocyte lymphocyte ratio predicts the new-onset of chronic kidney disease: A cohort study
Meng Zhang1, Kun Wang1, Huabo Zheng1
1Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Background And Aims:
The role of monocyte lymphocyte ratio (MLR) in predicting the risk of chronic kidney disease (CKD) is unclear, although inflammation contributes to the development of CKD. This study aimed to investigate whether elevated MLR predicts new-onset CKD.
Methods:
This study enrolled 14,033 consecutively Chinese participants. The primary outcome was the new-onset CKD defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2 or the presence of proteinuria after follow-up. After the descriptive analyses of baseline data, Univariate and multivariate Cox proportional models were used to evaluate the independent relationship between MLR and new-onset CKD.
Results:
11,280 participants were included in the final analysis, and 58.44% (n = 6592) of them were male. The mean age was 44.67 ± 12.85 years. After a median follow-up of 1.94 years, 2.55% (n = 288) of participants developed new-onset CKD. MLR was associated with the increased risk of CKD (HR = 16.12, 95% CI = 4.52-57.56, p < 0.0001). After adjustment for age, gender, body mass index, history of hypertension, systolic blood pressure, high-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, uric acid and estimated glomerular filtration rate, MLR remained an independent risk factor for CKD (HR = 8.89, 95%CI = 2.18-36.27, p = 0.0023).
Conclusion:
MLR is an independent predictor of the risk of CKD, which might be expected to better guide early prevention and treatment interventions.
Insights
The monocyte lymphocyte ratio (MLR) is a significant independent predictor of new-onset chronic kidney disease (CKD). This finding may help guide early prevention and treatment strategies for CKD.
Area of Science:
- Clinical Medicine
- Nephrology
- Inflammation Biomarkers
Background:
- Inflammation is implicated in chronic kidney disease (CKD) development.
- The predictive role of the monocyte lymphocyte ratio (MLR) for CKD risk remains unclear.
Purpose of the Study:
- To investigate if an elevated MLR predicts the incidence of new-onset CKD.
Main Methods:
- 11,280 Chinese participants were analyzed.
- New-onset CKD was defined as estimated glomerular filtration rate <60 mL/min/1.73 m² or proteinuria.
- Cox proportional models assessed the relationship between MLR and new-onset CKD.
Main Results:
- After a median follow-up of 1.94 years, 2.55% of participants developed new-onset CKD.
- Elevated MLR was associated with increased CKD risk (HR=16.12).
- MLR remained an independent predictor after adjusting for multiple risk factors (HR=8.89).
Conclusions:
- The monocyte lymphocyte ratio (MLR) is an independent predictor of new-onset CKD.
- MLR may aid in early CKD prevention and treatment interventions.
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