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Updated: Jan 2, 2026
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Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
Published on: March 11, 2021
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A framework for modeling radiation induced lymphopenia in radiotherapy
Jian-Yue Jin1, Todd Mereniuk2, Anirudh Yalamanchali2
1Department of Radiation Oncology, UHCMC/Case Western Reserve University, Cleveland, United States.
Summary
This study introduces a novel immune organ-at-risk (OAR) model to predict and minimize radiation-induced lymphopenia (RIL). The model accurately predicts lymphocyte counts, aiding radiotherapy treatment planning.
Area of Science:
- Radiation oncology
- Immunology
- Mathematical modeling
Background:
- Radiation-induced lymphopenia (RIL) is linked to patient survival.
- The immune system is not currently recognized as an organ-at-risk (OAR) in radiotherapy.
Purpose of the Study:
- To develop a framework for an immune OAR model.
- To predict and minimize RIL during radiotherapy.
Main Methods:
- A dynamic model of lymphocyte trafficking across five immune compartments was created.
- Radiation dose to lymphocytes was calculated based on immune compartment doses and blood flow.
- The RIL model incorporated lymphocyte dynamics, radiosensitivity, and reproductive capacity, fitted to patient absolute lymphocyte counts (ALC).
Main Results:
- The model demonstrated excellent fitting accuracy for 47 out of 51 patients (SSE < 4.0).
- Patient-specific in vivo estimation of lymphocyte radiosensitivity (median α = 0.40 Gy⁻¹) was achieved.
- Results align with previously reported in vitro radiosensitivity data.
Conclusions:
- A framework for an immune OAR model was successfully developed.
- This model shows potential for predicting and minimizing RIL in radiotherapy patients.
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