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Updated: Jan 2, 2026
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
Published on: July 28, 2013
Deformation based morphometry study of longitudinal MRI changes in behavioral variant frontotemporal dementia
Ana L Manera1, Mahsa Dadar1, D Louis Collins1
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801, University, Montreal, Quebec H3A 2B4, Canada.
Cerebral volume loss, particularly ventricle expansion, reliably identifies behavioural variant frontotemporal dementia (bvFTD) progression. This finding aids clinical trials for new bvFTD drugs and diagnosis.
Area of Science:
- Neuroimaging
- Neurology
- Biomarkers
Background:
- Behavioural variant frontotemporal dementia (bvFTD) diagnosis and treatment require objective measures.
- Cerebral volume loss patterns are key indicators of neurodegenerative diseases.
Purpose of the Study:
- To quantify cerebral volume loss in bvFTD for diagnostic and clinical trial applications.
- To assess atrophy progression and inform clinical trial sample size estimations.
Main Methods:
- Deformation-based morphometry (DBM) analyzed atrophy in 70 bvFTD patients and 133 controls.
- Follow-up assessments tracked changes over one year.
Main Results:
- bvFTD showed significant atrophy in frontal, insula, and temporal regions.
- Ventricle expansion was the most sensitive differentiator and progression marker for bvFTD.
Conclusions:
- Automated ventricular expansion measurement is a reliable bvFTD progression marker for clinical trials.
- DBM-derived ventricular expansion offers the lowest sample size estimates for bvFTD clinical trials.
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