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Biomedical Processing of Polyhydroxyalkanoates.

Dario Puppi¹, Gianni Pecorini¹, Federica Chiellini¹

¹Department of Chemistry and Industrial Chemistry, University of Pisa, UdR INSTM - Pisa, Via G. Moruzzi 13, 56124 Pisa, Italy.

Bioengineering (Basel, Switzerland)

|December 5, 2019

Summary

This summary is machine-generated.

Polyhydroxyalkanoates (PHA) are increasingly processed for biomedical uses due to their biocompatibility and biodegradability. This review covers PHA processing techniques for medical devices, from conventional methods to advanced fabrication.

Keywords:

additive manufacturing computer-aided wet-spinning electrospinning fused deposition modeling polyhydroxyalkanoates processing selective laser sintering

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Area of Science:

Biomaterials Science
Polymer Engineering
Biomedical Engineering

Background:

Polyhydroxyalkanoates (PHA) exhibit desirable properties like biocompatibility, biodegradability, and good mechanical behavior.
Their sustainable production potential further drives interest in PHA for various applications.
The unique characteristics of PHAs make them promising candidates for biomedical applications.

Purpose of the Study:

To provide a comprehensive overview of PHA processing techniques utilized in the biomedical field.
To discuss the fabrication of PHA-based devices and medical products for both experimental and commercial use.
To critically review scientific literature on PHA processing for biomedical applications.

Main Methods:

Discussion of conventional processing techniques such as solvent casting and melt-spinning.
Exploration of advanced fabrication approaches including electrospinning and additive manufacturing.
Analysis of PHA physical and processing properties in relation to processing technique requirements.

Main Results:

Detailed review of processing methods suitable for PHA biomaterials.
Examination of PHA homo- and copolymers, including poly(3-hydroxybutyrate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate), and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate).
Correlation of polymer properties with specific fabrication techniques for optimal device design.

Conclusions:

PHA processing methods are diverse, ranging from traditional to cutting-edge techniques.
The selection of processing methods depends on the specific PHA type and desired medical application.
Continued research into PHA processing is crucial for advancing their use in biomedical products.