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Related Experiment Video

Updated: Jan 2, 2026

Studying Cavitation Enhanced Therapy

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

Enhanced shockwave lithotripsy with active cavitation mitigation.

Hedieh Alavi Tamaddoni¹, William W Roberts², Timothy L Hall³

¹Department of Biomedical Engineering, University of Michigan, 2131 Carl A. Gerstacker Building, 2200 Bonisteel Boulevard, Ann Arbor, Michigan 48109, USA.

The Journal of the Acoustical Society of America

|December 5, 2019

Summary

This summary is machine-generated.

Acoustic pulses improve shockwave lithotripsy (SWL) by manipulating cavitation bubbles. This study optimized pulse timing to enhance stone fragmentation, significantly reducing residual fragments at higher SWL rates.

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Area of Science:

Acoustics
Biomedical Engineering
Medical Physics

Background:

Shockwave lithotripsy (SWL) efficacy can be limited by cavitation bubble dynamics.
Previous research indicated acoustic pulses enhance SWL by promoting bubble coalescence.

Purpose of the Study:

To investigate acoustical mechanisms for manipulating cavitation events to improve SWL efficacy at higher rates.
To evaluate the impact of acoustic pulse timing on cavitation bubble coalescence and dispersion, mitigating the shielding effect.

Main Methods:

In vitro experiments using a high-speed camera to observe bubble behavior.
Utilized a clinical lithotripter and an in-house transducer to apply acoustic pulses at varying time delays and pressures.
Tested on model kidney stones at 30 and 120 shocks/min.

Main Results:

The optimized acoustic pulse protocol significantly reduced untreated stone fragments greater than 2 mm from 15.81% to 0.19% at 120 shocks/min.
Demonstrated that controlled acoustic pulses can mitigate the shielding effect of residual bubbles.

Conclusions:

Acoustical manipulation of cavitation through optimized pulse timing is a viable strategy to enhance SWL effectiveness, especially at increased treatment rates.
This method offers a potential improvement for SWL procedures, leading to more efficient stone comminution.