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An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection
Published on: June 24, 2025
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Preventing sepsis development in complicated urinary tract infections
Nicola Petrosillo1, Guido Granata1, Breida Boyle2
1Systemic and Immunocompromised Host Infection Unit, National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Rome, Italy.
Expert Review of Anti-Infective Therapy
|December 5, 2019
Summary
Preventing sepsis in complicated urinary tract infections (cUTIs) requires prompt diagnosis and source control. Early intervention, including removing obstructions and appropriate antimicrobial therapy, is crucial for managing cUTIs and preventing sepsis progression.
Area of Science:
- Urology
- Infectious Diseases
- Critical Care Medicine
Background:
- Complicated urinary tract infections (cUTIs) are common and associated with higher treatment failure rates.
- Healthcare-associated cUTIs frequently involve multidrug-resistant organisms (MDROs).
- Sepsis development in cUTI poses significant risks.
Purpose of the Study:
- To review evidence on preventing sepsis in complicated urinary tract infections.
- To evaluate risk factors associated with sepsis development in cUTI patients.
Main Methods:
- Systematic literature search of MEDLINE and reference lists.
- Inclusion of articles published from January 2005 to September 2019.
- Focus on UTIs and sepsis prevention in complicated cases.
Main Results:
- Prompt diagnosis and identification of causative organisms are key.
- Source control, including removal of obstructions and drainage, is essential.
- Adequate and timely antimicrobial treatment is critical.
Conclusions:
- Effective sepsis prevention in cUTI hinges on rapid diagnosis and source control.
- Interventions such as removing urinary catheters, stents, and draining abscesses are vital.
- Appropriate antimicrobial strategies are necessary to prevent sepsis progression.
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