Prognostic value of interim 18F-FDG PET/CT in T-cell lymphomas

18F-FDG PET/CT is recommended for staging and response assessment in FDG-avid lymphomas, such as HL and DLBCL. But evidence of PET/CT regarding T-cell lymphomas (TCLs) was limited. In this retrospective study, we conducted survival analysis using interim PET/CT in 51 TCLs patients. PET/CT were reported using the Deauville 5-point score (DS) and the ΔSUV_max. In univariate analysis, I-PET/CT had a significant prognostic value of survival outcomes based on DS (p < .001 for progression-free survival (PFS), p = .010 for overall survival (OS)) and ΔSUV_max (p < .001 for PFS, p = .023 for OS). In multivariate analysis, DS remained a statistically independent predictor of PFS (p < .001) and OS (p = .017). ΔSUV_max remained a statistically independent predictor of PFS (p = .008), but not of OS (p = 0.311). Therefore, DS on I-PET/CT had a remarkable value of predicting survival outcomes in TCLs.