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Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis.

Damiano Pizzol1, Jacopo Demurtas2, Brendon Stubbs3,4,5

  • 1Italian Agency for Development Cooperation, Jerusalem, Israel.

American Journal of Men'S Health
|December 5, 2019
PubMed
Summary
This summary is machine-generated.

Cannabis use is linked to a higher risk of erectile dysfunction (ED). This review found ED prevalence was 69.1% in cannabis users versus 34.7% in non-users, suggesting a significant association.

Keywords:
Cannabiserectile dysfunctionmeta-analysisprevalencesystematic review

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Area of Science:

  • Urology
  • Andrology
  • Pharmacology

Background:

  • Global cannabis use and legalization are increasing.
  • Cannabis has potential therapeutic effects but also undefined health risks.
  • Erectile dysfunction (ED) is a common male sexual disorder with potential links to cannabis use.

Purpose of the Study:

  • To systematically review and summarize the prevalence and risk of ED in cannabis users compared to non-users.
  • To collate existing literature on the association between cannabis consumption and ED.

Main Methods:

  • Systematic review of major databases (inception to January 1, 2019).
  • Inclusion of five case-control studies with data from 3,395 men (1,035 cannabis users, 2,360 controls).
  • Random-effect model used to calculate odds ratio (OR) and 95% confidence intervals (CI) for ED.

Main Results:

  • Overall ED prevalence was 69.1% in cannabis users versus 34.7% in controls.
  • Cannabis users had nearly four times the odds of ED compared to controls (OR = 3.83; 95% CI: 1.30-11.28; p = .02).
  • High heterogeneity (I² = 90%) was noted, with prediction intervals overlapping 1.00.

Conclusions:

  • Data suggest ED is approximately twice as high in cannabis users compared to controls.
  • Further longitudinal research is required to confirm these findings.
  • Future studies should explore a potential dose-response relationship between cannabis and ED.