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Characterization of Functionally Associated miRNAs in Glioblastoma and their Engineering into Artificial Clusters for Gene Therapy
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Aberrantly expressed microRNAs and their implications in childhood central nervous system tumors

Julia Alejandra Pezuk1, Karina Bezerra Salomão2, Mirella Baroni2

  • 1Anhanguera University of São Paulo, UNIAN/SP, Av. Dr. Rudge Ramos, 1501 - Jardim Abc, São Bernardo do Campo, SP, 09639-000, Brazil.

Cancer Metastasis Reviews
|December 5, 2019
PubMed

Insights

MicroRNAs (miRNAs) show promise as biomarkers for pediatric central nervous system (CNS) tumors. Further research into miRNA profiling can improve diagnosis, prognosis, and targeted therapies for these aggressive childhood cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Childhood central nervous system (CNS) tumors remain a significant cause of mortality despite treatment advances.
  • Identifying molecular targets is crucial for improved diagnostics, prognostics, and targeted therapies.
  • MicroRNAs (miRNAs) are increasingly recognized for their role in cancer development and progression.

Purpose of the Study:

  • To provide an overview of recent advances in the diagnostic and prognostic potential of miRNAs in pediatric CNS tumors.
  • To highlight the scarcity of microRNA profiling studies in pediatric tumors.
  • To explore the role of miRNA dysregulation as an epigenetic driver of tumorigenesis.

Main Methods:

  • Literature review of recent advances in miRNA research for pediatric CNS tumors.
  • Focus on specific tumor types: medulloblastoma, ependymoma, pilocytic astrocytoma, glioblastoma, diffuse intrinsic pontine glioma, atypical teratoid/rhabdoid tumors, and choroid plexus tumors.
  • Analysis of the diagnostic, prognostic, and therapeutic implications of miRNA dysregulation.

Main Results:

  • MicroRNA dysregulation is implicated as an epigenetic driver in tumorigenesis.
  • Recent advances demonstrate the diagnostic and prognostic potential of miRNAs in various pediatric CNS tumors.
  • MicroRNA profiling offers a promising avenue for targeted therapeutic strategies.

Conclusions:

  • MicroRNAs hold significant potential as biomarkers for pediatric CNS tumors.
  • Further microRNA profiling studies are warranted to fully elucidate their role in diagnosis, prognosis, and treatment response.
  • Targeted therapies based on miRNA modulation could revolutionize childhood CNS cancer treatment.
Keywords:
CancerCentral nervous systemChildrenReviewmiRNA

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