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Related Concept Videos

Overview of Exosomes01:36

Overview of Exosomes

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Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
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Related Experiment Video

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Formulating and Characterizing an Exosome-based Dopamine Carrier System
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Sustained Delivery System for Stem Cell-Derived Exosomes.

Andri K Riau1, Hon Shing Ong1,2,3, Gary H F Yam1,3

  • 1Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore, Singapore.

Frontiers in Pharmacology
|December 5, 2019
PubMed
Summary
This summary is machine-generated.

Exosomes offer therapeutic benefits but face rapid clearance. Exosome-loaded hydrogels provide a sustained, localized delivery solution, overcoming administration challenges for enhanced therapeutic outcomes.

Keywords:
biomaterialsexosomeshydrogelregenerative medicinestem cellsustained delivery

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Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Stem cell paracrine action is mediated by exosomes, crucial for intercellular communication.
  • Exosomes exhibit therapeutic potential in skin regeneration and cardiac recovery.
  • Conventional exosome administration faces rapid clearance and biodistribution issues.

Purpose of the Study:

  • To review challenges in conventional exosome administration.
  • To highlight exosome-incorporated hydrogels as a solution for sustained delivery.
  • To discuss encapsulation techniques and hydrogel examples for exosome delivery systems.

Main Methods:

  • Literature review of exosome administration challenges.
  • Exploration of hydrogel-based delivery systems for exosomes.
  • Analysis of techniques for exosome encapsulation in hydrogels.

Main Results:

  • Conventional exosome administration leads to rapid clearance and off-target accumulation.
  • Biodegradable and porous hydrogels enable sustained and localized exosome release.
  • Hydrogels protect exosomes from premature degradation and clearance.

Conclusions:

  • Exosome-incorporated hydrogels represent a promising strategy to overcome limitations of conventional exosome delivery.
  • This approach enhances therapeutic efficacy through sustained and localized exosome release.
  • Further research into encapsulation techniques and hydrogel materials is warranted.