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Updated: Jan 2, 2026

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings

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Published on: October 25, 2015

Transcriptome Analysis Identifies Candidate Genes and Pathways Associated With Feed Efficiency in Hu Sheep.

Deyin Zhang¹, Xiaoxue Zhang^1,2, Fadi Li^1,2,3

¹College of Animal Science and Technology, Gansu Agricultural University, Lanzhou, China.

Frontiers in Genetics

|December 5, 2019

Summary

Understanding sheep feed efficiency (FE) is key for livestock improvement. This study identified key genes and genetic variants in Hu lambs, offering insights into molecular mechanisms for enhancing FE through genetic selection.

Keywords:

differentially expressed gene feed efficiency residual feed intake sheep single nucleotide polymorphism

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Published on: January 30, 2017

Area of Science:

Animal Genetics
Livestock Science
Molecular Biology

Background:

Residual feed intake (RFI) is a crucial economic trait in livestock and poultry breeding.
The genetic regulation of RFI in sheep remains largely uncharacterized, hindering genetic improvement efforts.

Purpose of the Study:

To investigate the genetic regulatory mechanisms of RFI in Hu lambs.
To identify candidate genes and genetic variants associated with feed efficiency (FE) in sheep.

Main Methods:

Phenotypic measurement of feed efficiency-related traits in 137 male Hu lambs.
Liver transcriptome analysis of lambs with extreme RFI values (high vs. low).
Differential gene expression analysis, pathway enrichment, and SNP scanning for candidate genes (ADRA2A, RYR2).

Main Results:

101 differentially expressed genes were identified between low-RFI and high-RFI groups.
Downregulated genes were linked to immune function; upregulated genes were associated with energy metabolism.
Two synonymous mutations in ADRA2A and RYR2 were significantly associated with feed conversion rate.

Conclusions:

This study elucidates molecular mechanisms underlying FE regulation in sheep.
Identified ADRA2A and RYR2 genes and specific variants offer potential targets for genetic improvement of FE in sheep populations.