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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

3D cellular-resolution imaging in arteries using few-mode interferometry.

Biwei Yin¹, Zhonglie Piao¹, Kensuke Nishimiya¹

¹1Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114 USA.

Light, Science & Applications

|December 5, 2019

Summary

This summary is machine-generated.

This study introduces a new intravascular imaging system using few-mode interferometry to achieve high-resolution, 3D visualization of cellular structures in arteries. This breakthrough enables precise study and diagnosis of atherosclerosis in vivo.

Keywords:

Biophotonics Fibre optics and optical communications Imaging and sensing

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High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

High-resolution Fiber-optic Microendoscopy for in situ Cellular Imaging

Published on: January 11, 2011

Area of Science:

Biomedical Engineering
Medical Imaging
Cardiovascular Research

Background:

Atherosclerosis involves cellular and subcellular changes within artery walls.
Conventional intravascular imaging techniques like optical coherence tomography (OCT) have limitations in resolution-depth of focus tradeoff.
High-resolution imaging of atherosclerosis in vivo is crucial for understanding disease mechanisms and improving diagnostics.

Purpose of the Study:

To develop an intravascular imaging system capable of 3D cellular-resolution imaging in vivo.
To overcome the depth-of-focus limitations of existing high-resolution intravascular imaging methods.
To enable precise visualization of cellular and subcellular structures within the artery wall.

Main Methods:

Development of an intravascular imaging system and catheter utilizing few-mode interferometry.
Overcoming the depth of focus limitation inherent in conventional focusing optics.
Acquiring 3D intravascular images in vivo using a submillimeter diameter, flexible catheter.

Main Results:

Successfully achieved 3D cellular-resolution intravascular imaging in vivo.
Visualized distinct cellular and subcellular structures, including crystals, smooth muscle cells, and inflammatory cells, within artery walls.
Acquired high-resolution images from diseased human coronary arteries and living rabbit arteries.

Conclusions:

The developed few-mode interferometry system overcomes previous resolution-depth limitations for intravascular imaging.
This technology enables unprecedented precision in studying and diagnosing human coronary artery disease.
Future applications include enhanced research into atherosclerosis pathogenesis and improved clinical diagnostic capabilities.