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Evaluating the scope of intramedullary invasion of malignant bone tumor by DCE-MRI quantitative parameters in animal
Yuan Zhang1,2, Yiqing Tan1, Cheng Dong2
1Department of Radiology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, 430000, Hubei, China.
Abstract:
The purpose was to analyze the value of quantitative parameters of DCE-MRI in evaluating micro-infiltration of malignant bone tumors.
Methods:
Thirty-nine New Zealand white rabbits were used to establish malignant bone tumor models by implanting VX2 tumor fragments into the right tibiae. After three weeks, models were examined by conventional MRI and DCE-MRI; then the right tibiae were cut into sagittal sections and partitioned into histology slices for comparison with microscopic findings. Micro-infiltration groups were selected and the range of infiltration was determined under the microscope, and corresponding DCE images analyzed to obtain the quantitative parameters include Ktrans, Kep, v and v in parenchyma areas, micro-infiltration areas and simple edema areas. One-way ANOVA was used to compare the differences of the parameters between the three areas. Receiver operating characteristic curves (ROCs) were plotted to determine the accuracy of different parameters by area under curves (AUCs).
Results:
22 cases (22/39, 56.4%) were included in the micro-infiltration group and the infiltration depth ranged from 1.3 mm to 4.6 mm, with an average depth of 3.2 mm ± 0.8 mm. The statistical results of quantitative parameters in the three areas were as follows: Ktrans values were (0.494 ± 0.052), (0.403 ± 0.049), (0.173 ± 0.047) min-1 (p = =0.000), Kep values were (1.959 ± 0.65), (1.528 ± 0.372), (1.174 ± 0.486) min-1 (p = =0.000), v values were (0.247 ± 0.068), (0.283 ± 0.057), (0.168 ± 0.062) min-1 (p = =0.000), v values were (0.125 ± 0.036), (0.108 ± 0.033), (0.098 ± 0.025) min-1 (p = =0.022), respectively. Ktrans and Kep values had significant difference in the three areas after comparing between-groups, respectively. However, there were no significant difference in v values between parenchyma and micro-infiltration areas (p = =0.078), micro-infiltration and simple edema areas (p = =0.315), and v values between parenchyma and micro-infiltration areas (p = =0.056). The v values were higher in parenchyma and micro-infiltration areas then simple edema areas. Ktrans had highest accuracy in differentiating different areas (AUC > 0.9), respectively.
Conclusion:
Quantitative parameters Ktrans, Kep and v can assess the extent of intramedullary invasion of malignant bone tumors. Ktrans have highest accuracy in differentiating different regions.
Insights
Quantitative parameters from dynamic contrast-enhanced MRI (DCE-MRI) can assess micro-infiltration in malignant bone tumors. Ktrans and Kep values effectively differentiate tumor invasion areas, with Ktrans showing the highest accuracy.
Area of Science:
- Oncology
- Radiology
- Medical Imaging
Background:
- Malignant bone tumors pose a significant challenge in clinical oncology.
- Accurate assessment of tumor invasion is crucial for effective treatment planning.
- Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) offers quantitative insights into tissue microvasculature and permeability.
Purpose of the Study:
- To evaluate the diagnostic value of quantitative DCE-MRI parameters in assessing the micro-infiltration of malignant bone tumors.
- To correlate DCE-MRI findings with histological assessments of tumor invasion.
- To determine which quantitative parameters are most effective in differentiating tumor infiltration.
Main Methods:
- Malignant bone tumor models were established in New Zealand white rabbits using VX2 tumor fragments.
- Conventional MRI and DCE-MRI were performed on tumor-bearing tibiae.
- Quantitative parameters (Ktrans, Kep, v, v) were analyzed in parenchyma, micro-infiltration, and edema areas.
- Statistical analysis (ANOVA) and Receiver Operating Characteristic (ROC) curves were used to assess parameter differences and diagnostic accuracy.
Main Results:
- Micro-infiltration was detected in 56.4% of cases, with an average depth of 3.2 mm.
- Significant differences in Ktrans and Kep values were observed between parenchyma, micro-infiltration, and edema areas (p < 0.001).
- Ktrans demonstrated the highest accuracy (AUC > 0.9) in differentiating these regions, followed by Kep.
Conclusions:
- Quantitative DCE-MRI parameters, specifically Ktrans and Kep, are valuable for assessing intramedullary invasion in malignant bone tumors.
- Ktrans is the most accurate parameter for differentiating tumor infiltration zones.
- DCE-MRI provides objective metrics to complement histological evaluation in bone tumor management.