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Data on hydroxychloroquine interference with urine laboratory testing.

Jennie M Kingery1, Joshua B Radke2, Jon Maakestad1

  • 1Department of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA, 52242, USA.

Data in Brief
|December 5, 2019
PubMed
Summary
This summary is machine-generated.

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Hydroxychloroquine overdose can interfere with urine drug tests. This study investigated hydroxychloroquine

Area of Science:

  • Clinical Chemistry
  • Toxicology
  • Pharmacology

Background:

  • Hydroxychloroquine (HCQ) is used for autoimmune diseases.
  • HCQ and chloroquine can interfere with urine chemistry tests.
  • High HCQ concentrations may affect specific assays.

Purpose of the Study:

  • To investigate the interference of HCQ with common urine assays.
  • To provide raw data for 24 urine assays investigated.
  • To support findings related to HCQ intoxication diagnostic pitfalls.

Main Methods:

  • Spiked pooled de-identified urine specimens with HCQ.
  • Investigated 24 different urine assays.
  • Collected raw data for analysis.

Main Results:

Keywords:
Absorbance errorAssay interferenceClinical chemistry testsDrug of abuse testingHydroxychloroquinePhotometry

Related Experiment Videos

  • Observed suspected interference in urine drug of abuse testing.
  • Documented interference at high urine HCQ concentrations (>500 mg/L).
  • Provided raw data for 24 urine assays.

Conclusions:

  • Hydroxychloroquine can cause significant interference in urine laboratory testing.
  • Awareness of HCQ interference is crucial for accurate diagnosis in overdose cases.
  • This dataset aids in understanding HCQ's impact on clinical laboratory assays.