Related Experiment Video
Updated: Oct 1, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
The effect of spermidine on guanine decomposition via photoinduced electron transfer in DNA
Mayu Esumi1, Shunsuke Sakurai, Makiko Tanaka
1Department of Engineering Science, Graduate School of Informatics and Engineering, The University of Electro-Communications, 1-5-1 Chofugaoka, Chofu, Tokyo 182-8585E, Japan. makiko.tanaka@uec.ac.jp.
Abstract:
Spermidine, a trivalent organic cation, induced DNA structural changes and suppressed guanine photooxidative decomposition via electron transfer through pyrene-modified DNA. On the other hand, adding higher concentrations of spermidine resulted in DNA condensation. The efficiency of guanine decomposition in condensed pyrene-modified DNA was promoted remarkably.
More Related Videos
14:27Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
Published on: August 19, 2013
12:15Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
Published on: May 29, 2019
Related Concept Videos
Proofreading
DNA Damage can Stall the Cell Cycle
Maxam-Gilbert Sequencing
Challenges of the Maxam-Gilbert Method
The...
Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Proofreading
Errors During Replication are Corrected by the DNA Polymerase Enzyme
Spontaneous and Induced Mutations