Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nonlinear Input-Output Functions of Motoneurons.

Marc D Binder1, Randall K Powers1, C J Heckman2

  • 1Department of Physiology & Biophysics, University of Washington School of Medicine, Seattle, Washington.

Physiology (Bethesda, Md.)
|December 5, 2019
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Riluzole treatment paradoxically increases motoneuron excitability in ALS due to hyperactive homeostasis.

bioRxiv : the preprint server for biology·2026
Same author

A new perspective on spinal motoneuron persistent currents: Predictive compensation for muscle nonlinearities.

The Journal of physiology·2026
Same author

Motor unit discharge properties are modestly influenced by menstrual cycle-related fluctuations in sex hormone concentrations.

bioRxiv : the preprint server for biology·2026
Same author

A novel protocol to investigate the monoaminergic relationship between descending nociceptive and motor unit neuromodulation.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Loss of 5-HT<sub>2C</sub> receptor function alters motor behavior in male and female mice with and without spinal cord injury.

Frontiers in neural circuits·2025
Same author

Post-inhibitory rebound excitation drives extensor activity following spinal cord stimulation.

Brain stimulation·2025
Same journal

Evolution of Adaptive Non-Shivering Thermogenesis in Mammals.

Physiology (Bethesda, Md.)·2026
Same journal

The Iron Lung: Ferroptosis and Iron Regulation in Aging and Lung Diseases.

Physiology (Bethesda, Md.)·2026
Same journal

RNA-Protein complexes and their role in cell fate.

Physiology (Bethesda, Md.)·2026
Same journal

Ion Channels as Gatekeepers of Fertility: From Uterine Kir7.1 to Sperm CatSper.

Physiology (Bethesda, Md.)·2026
Same journal

Is insulin resistance an adaptive response? Clues from nature.

Physiology (Bethesda, Md.)·2026
Same journal

Physiology in Perspective.

Physiology (Bethesda, Md.)·2026
See all related articles

Motoneurons control all movements, but their complex behavior, due to persistent inward currents (PICs), challenges motor control modeling. Understanding these nonlinearities is key to advancing our knowledge of motor commands.

Area of Science:

  • Neuroscience
  • Motor Control
  • Computational Neuroscience

Background:

  • Motoneurons are the final output pathway for all motor commands.
  • Their input-output properties are crucial for generating movement.
  • Nonlinear behaviors in motoneurons present a significant challenge to understanding motor control.

Purpose of the Study:

  • To review the role of persistent inward currents (PICs) in motoneuronal discharge.
  • To examine how PICs contribute to the nonlinear properties of motoneurons.
  • To discuss the implications of these nonlinearities for motor control modeling.

Main Methods:

  • Literature review focusing on motoneuronal physiology.
  • Analysis of voltage-gated Na+ and Ca2+ channel contributions to PICs.
Keywords:
input-output functionmotoneuronnonlinear behaviorpersistent inward currents

Related Experiment Videos

  • Discussion of computational modeling challenges.

    • Main Results:

    • Persistent inward currents (PICs) significantly influence motoneuronal firing patterns.
    • PICs, mediated by voltage-gated channels, introduce substantial nonlinearities.
    • These nonlinearities complicate the accurate prediction of motoneuron output.

    Conclusions:

    • PICs are a critical factor in motoneuronal function and motor command processing.
    • The nonlinear dynamics introduced by PICs impede the development of comprehensive motor control models.
    • Further research is needed to effectively incorporate PICs into computational models.