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General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases
Zhicheng Zhang1, Alexis J Cepeda, Mireya L Robles
1Department of Chemistry, The University of Texas at Austin, 100 E. 24th St., Austin, TX 78712, USA.
Chemical Communications (Cambridge, England)
|December 5, 2019
Abstract:
Modular polyketide synthases (PKSs) are enzymatic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.