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The nanostructured secretome.

S Busatto1, A Zendrini, A Radeghieri

  • 1Department of Molecular and Translational Medicine, University of Brescia, 25123 Brescia, Italy. paolo.bergese@unibs.it.

Biomaterials Science
|December 5, 2019
PubMed
Summary
This summary is machine-generated.

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The cell secretome should include secreted nanoparticles (secNPs), crucial for physiological processes and promising in cell-free therapeutics. Further research is needed to fully exploit their nanomedicine potential.

Area of Science:

  • Nanomedicine
  • Cell Biology
  • Biotechnology

Background:

  • The traditional definition of the cell secretome focuses on proteins, overlooking secreted nanoparticles (secNPs).
  • secNPs, including lipoproteins and extracellular vesicles, are increasingly recognized as key regulators in physiological and pathological processes.
  • These cell-derived nanoparticles offer potential as advanced therapeutics and diagnostics.

Purpose of the Study:

  • To propose an expanded definition of the secretome encompassing secNPs.
  • To consolidate current knowledge on secNPs, from biogenesis to clinical applications.
  • To highlight the need for multidisciplinary efforts in secNP research and development.

Main Methods:

  • This review synthesizes existing literature on secNPs.

Related Experiment Videos

  • It analyzes the biogenesis, colloidal properties, and engineering potential of secNPs.
  • Comparative analysis of different secNP classes is facilitated through a unified framework.

    • Main Results:

    • The study advocates for including secNPs in the secretome definition due to their regulatory roles.
    • secNPs show promise as sustainable, targeted nanomedicines, overcoming limitations of synthetic nanoparticles.
    • A comprehensive framework is presented to guide future research and exploitation of secNPs.

    Conclusions:

    • Expanding the secretome concept to include secNPs is essential for advancing nanomedicine.
    • Further research into secNP properties and bioprocesses is critical for clinical translation.
    • Multidisciplinary collaboration is key to unlocking the full potential of secNPs in diagnostics and therapeutics.